7AL9
human GTP cyclohydrolase I feedback regulatory protein (GFRP) in complex with phenylalanine
Summary for 7AL9
| Entry DOI | 10.2210/pdb7al9/pdb |
| Descriptor | GTP cyclohydrolase 1 feedback regulatory protein, POTASSIUM ION, PHENYLALANINE, ... (4 entities in total) |
| Functional Keywords | gtp cyclohydrolase 1 feedback regulatory protein, regulatory protein, l-phenylalanine binding (phe) synthesis allosteric regulation, protein binding |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 10 |
| Total formula weight | 101967.70 |
| Authors | Ebenhoch, R.,Nar, H. (deposition date: 2020-10-06, release date: 2021-10-13, Last modification date: 2024-02-07) |
| Primary citation | Ebenhoch, R.,Prinz, S.,Kaltwasser, S.,Mills, D.J.,Meinecke, R.,Rubbelke, M.,Reinert, D.,Bauer, M.,Weixler, L.,Zeeb, M.,Vonck, J.,Nar, H. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117:31838-31849, 2020 Cited by PubMed: 33229582DOI: 10.1073/pnas.2013473117 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.745 Å) |
Structure validation
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