7ALA

human GCH-GFRP inhibitory complex

Summary for 7ALA

Entry DOI	10.2210/pdb7ala/pdb
Descriptor	GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ZINC ION, ... (6 entities in total)
Functional Keywords	gtp cyclohydrolase 1, gtpch1, gtp cyclohydrolase i regulatory protein, gfrp, allosteric regulation, complex, allosteric inhibitor, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	10
Total formula weight	169230.85
Authors	Ebenhoch, R.,Nar, H. (deposition date: 2020-10-06, release date: 2021-10-13, Last modification date: 2024-02-07)
Primary citation	Ebenhoch, R.,Prinz, S.,Kaltwasser, S.,Mills, D.J.,Meinecke, R.,Rubbelke, M.,Reinert, D.,Bauer, M.,Weixler, L.,Zeeb, M.,Vonck, J.,Nar, H. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117:31838-31849, 2020 Cited by PubMed: 33229582 DOI: 10.1073/pnas.2013473117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.846 Å)

Structure validation