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8KH4
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BU of 8kh4 by Molmil
Cryo-EM structure of the GPR161-Gs complex
分子名称: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Nie, Y, Qiu, Z, Zheng, S, Chen, S.
登録日2023-08-21
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
8KH5
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BU of 8kh5 by Molmil
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Nie, Y, Qiu, Z, Zheng, S, Chen, S.
登録日2023-08-21
公開日2023-10-18
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
8KGK
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BU of 8kgk by Molmil
Cryo-EM structure of the GPR61-Gs complex
分子名称: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Nie, Y, Qiu, Z, Zheng, S.
登録日2023-08-19
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
4ZLK
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BU of 4zlk by Molmil
Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin
分子名称: CALCIUM ION, Calmodulin, Unconventional myosin-Va
著者Shen, M, Zhang, N, Zheng, S, Zhang, W.-B, Zhang, H.-M, Lu, Z, Su, Q.P, Sun, Y, Ye, K, Li, X.-D.
登録日2015-05-01
公開日2016-05-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Structural basis for calcium regulation of myosin 5 motor function
To Be Published
5WXL
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BU of 5wxl by Molmil
Crystal structure of the Rrs1 and Rpf2 complex
分子名称: Regulator of ribosome biosynthesis, Ribosome biogenesis protein RPF2
著者Ye, K, Zheng, S.
登録日2017-01-07
公開日2017-01-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular architecture of the 90S small subunit pre-ribosome
Elife, 6, 2017
5W3K
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BU of 5w3k by Molmil
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex NADPH, Mg2+ and CPD
分子名称: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Patel, K.M, Teran, D, Zheng, S, Kandale, A, Schembri, M, McGeary, R.P, Schenk, G, Guddat, L.W.
登録日2017-06-08
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.589 Å)
主引用文献Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.
Chemistry, 23, 2017
5WXM
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BU of 5wxm by Molmil
Crystal structure of the Imp3 and Mpp10 complex
分子名称: SULFATE ION, U3 small nucleolar RNA-associated protein MPP10, U3 small nucleolar ribonucleoprotein protein IMP3
著者Ye, K, Zheng, S.
登録日2017-01-07
公開日2017-06-28
実験手法X-RAY DIFFRACTION (2.304 Å)
主引用文献Molecular architecture of the 90S small subunit pre-ribosome
Elife, 6, 2017
5HK2
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BU of 5hk2 by Molmil
Human sigma-1 receptor bound to 4-IBP
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, N-(1-benzylpiperidin-4-yl)-4-iodobenzamide, SULFATE ION, ...
著者Schmidt, H.R, Zheng, S, Gurpinar, E.G, Koehl, A, Manglik, A, Kruse, A.C.
登録日2016-01-13
公開日2016-04-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the human sigma 1 receptor.
Nature, 532, 2016
6C5N
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BU of 6c5n by Molmil
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1
分子名称: (cyclopentylamino)(oxo)acetic acid, IMIDAZOLE, Ketol-acid reductoisomerase (NADP(+)), ...
著者Kandale, A, Patel, K.M, Zheng, S, You, L, Guddat, L.W, Schenk, G, Schembri, M.A, McGeary, R.P.
登録日2018-01-16
公開日2019-01-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.673 Å)
主引用文献Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductosiomerase (KARI) inhibitor
To Be Published
5HK1
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BU of 5hk1 by Molmil
Human sigma-1 receptor bound to PD144418
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-(4-methylphenyl)-5-(1-propyl-3,6-dihydro-2H-pyridin-5-yl)-1,2-oxazole, SULFATE ION, ...
著者Schmidt, H.R, Zheng, S, Gurpinar, E, Koehl, A, Manglik, A, Kruse, A.C.
登録日2016-01-13
公開日2016-04-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.5051 Å)
主引用文献Crystal structure of the human sigma 1 receptor.
Nature, 532, 2016
6D35
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BU of 6d35 by Molmil
Crystal structure of Xenopus Smoothened in complex with cholesterol
分子名称: CHOLESTEROL, Smoothened,Soluble cytochrome b562,Smoothened
著者Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A.
登録日2018-04-14
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell, 174, 2018
6D32
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BU of 6d32 by Molmil
Crystal structure of Xenopus Smoothened in complex with cyclopamine
分子名称: Cyclopamine, Smoothened,Soluble cytochrome b562,Smoothened
著者Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A.
登録日2018-04-14
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.751 Å)
主引用文献Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell, 174, 2018
6AQJ
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BU of 6aqj by Molmil
Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity.
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Ketol-acid reductoisomerase (NADP(+)), ...
著者Patel, K.M, Teran, D, Zheng, S, Gracia, M, Lv, Y, Schembri, M.A, McGeary, R.P, Schenk, G, Guddat, L.W.
登録日2017-08-20
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.373 Å)
主引用文献Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.
Chemistry, 23, 2017
6BUL
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BU of 6bul by Molmil
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2
分子名称: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Kandale, A, Patel, K.M, Zheng, S, You, L, Guddat, L.W, Schenk, G, Schembri, M.A, McFeary, R.P.
登録日2017-12-10
公開日2018-12-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductoisomerase (KARI) inhibitors
To Be Published
6C55
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BU of 6c55 by Molmil
Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3
分子名称: (cyclohexylamino)(oxo)acetic acid, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, ...
著者Kandale, A, Patel, K.M, Zheng, S, You, L, Guddat, L.W, Schenk, G, Schmbri, M, McGeary, R.P.
登録日2018-01-14
公開日2019-01-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductoisomerase (KARI) inhibitors
To Be Published
8J7Q
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BU of 8j7q by Molmil
The active site mutant of human inorganic pyrophosphatase
分子名称: Inorganic pyrophosphatase
著者Hu, F, Zheng, S.
登録日2023-04-28
公開日2024-04-03
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献The active site mutant of human inorganic pyrophosphatase
To Be Published
8I79
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BU of 8i79 by Molmil
Cryo-EM structure of KCTD7 in complex with Cullin3
分子名称: BTB/POZ domain-containing protein KCTD7, Cullin-3
著者Jiang, W, Wang, W, Zheng, S.
登録日2023-01-31
公開日2023-07-26
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.
Sci Adv, 9, 2023
3TAD
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BU of 3tad by Molmil
Crystal Structure of the Liprin-alpha/Liprin-beta complex
分子名称: GLYCEROL, Liprin-alpha-2, Liprin-beta-1
著者Wei, Z, Zheng, S, Yu, C, Zhang, M.
登録日2011-08-04
公開日2011-10-12
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures
Mol.Cell, 43, 2011
3TAC
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BU of 3tac by Molmil
Crystal Structure of the Liprin-alpha/CASK complex
分子名称: CHLORIDE ION, Liprin-alpha-2, Peripheral plasma membrane protein CASK, ...
著者Wei, Z, Zheng, S, Yu, C, Zhang, M.
登録日2011-08-03
公開日2011-10-12
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures
Mol.Cell, 43, 2011
5YAX
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BU of 5yax by Molmil
Crystal structure of a human neutralizing antibody bound to a HBV preS1 peptide
分子名称: Large envelope protein, SODIUM ION, scFv1 antibody
著者Liu, X, Zheng, S, Ye, K, Sui, J.
登録日2017-09-02
公開日2017-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A potent human neutralizing antibody Fc-dependently reduces established HBV infections
Elife, 6, 2017
6KTR
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BU of 6ktr by Molmil
Crystal structure of fibroblast growth factor 19 in complex with Fab
分子名称: Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ...
著者Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J.
登録日2019-08-28
公開日2020-07-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.59775758 Å)
主引用文献Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.
Cancer Sci., 111, 2020
7Y26
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BU of 7y26 by Molmil
Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex
分子名称: Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Chen, S, Zheng, S.
登録日2022-06-09
公開日2022-10-19
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
7Y27
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BU of 7y27 by Molmil
Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex
分子名称: CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Chen, S, Zheng, S.
登録日2022-06-09
公開日2022-10-19
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (3.48 Å)
主引用文献Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
7Y24
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BU of 7y24 by Molmil
Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ...
著者Chen, S, Zheng, S.
登録日2022-06-09
公開日2022-10-19
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
7X2F
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BU of 7x2f by Molmil
Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex
分子名称: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Teng, X, Zheng, S.
登録日2022-02-25
公開日2022-06-15
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Ligand recognition and biased agonism of the D1 dopamine receptor.
Nat Commun, 13, 2022

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