6C55

Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3

Summary for 6C55

• Entry DOI: 10.2210/pdb6c55/pdb
• Descriptor: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• Functional Keywords: ketol-acid reductoisomerase, inhibitor, oxidoreductase
• Biological source: Staphylococcus aureus (strain bovine RF122 / ET3-1)
• Total number of polymer chains: 2
• Total formula weight: 77886.90

Authors

Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schmbri, M.,McGeary, R.P. (deposition date: 2018-01-14, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schmbri, M.,McGeary, R.P.; Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductoisomerase (KARI) inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.09 Å)