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6BUL

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2

Summary for 6BUL
Entry DOI10.2210/pdb6bul/pdb
DescriptorKetol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywordsketol-acid reductoisomerase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceStaphylococcus aureus (strain bovine RF122 / ET3-1)
Total number of polymer chains2
Total formula weight78162.12
Authors
Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McFeary, R.P. (deposition date: 2017-12-10, release date: 2018-12-12, Last modification date: 2023-10-04)
Primary citationKandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McFeary, R.P.
Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductoisomerase (KARI) inhibitors
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.88 Å)
Structure validation

217705

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