6BUL
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0009099 | biological_process | L-valine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004455 | molecular_function | ketol-acid reductoisomerase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0009099 | biological_process | L-valine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | MG402 |
| A | E9G404 |
| A | E9J405 |
| A | HOH524 |
| A | HOH601 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | E9G404 |
| A | E9J405 |
| A | HOH501 |
| A | HOH551 |
| A | HOH571 |
| B | HOH508 |
| A | ASP190 |
| A | MG401 |
| site_id | AC3 |
| Number of Residues | 37 |
| Details | binding site for residue NAP A 403 |
| Chain | Residue |
| A | TYR25 |
| A | GLY26 |
| A | SER27 |
| A | GLN28 |
| A | ILE47 |
| A | ARG48 |
| A | SER52 |
| A | LEU79 |
| A | LEU80 |
| A | PRO81 |
| A | ASP82 |
| A | GLN85 |
| A | VAL88 |
| A | ALA106 |
| A | HIS107 |
| A | PRO129 |
| A | GLY131 |
| A | PRO132 |
| A | GLY133 |
| A | E9G404 |
| A | E9J405 |
| A | HOH519 |
| A | HOH523 |
| A | HOH553 |
| A | HOH557 |
| A | HOH561 |
| A | HOH569 |
| A | HOH583 |
| A | HOH601 |
| A | HOH607 |
| A | HOH629 |
| A | HOH633 |
| A | HOH663 |
| B | SER249 |
| B | ILE250 |
| B | SER251 |
| B | HOH585 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| B | ASP190 |
| B | GLU194 |
| B | E9G401 |
| B | E9J402 |
| B | MG404 |
| B | HOH521 |
| B | HOH597 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 404 |
| Chain | Residue |
| A | HOH520 |
| B | ASP190 |
| B | E9G401 |
| B | E9J402 |
| B | MG403 |
| B | HOH501 |
| B | HOH551 |
| B | HOH598 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | binding site for residue NAP B 405 |
| Chain | Residue |
| A | SER249 |
| A | ILE250 |
| A | SER251 |
| B | TYR25 |
| B | GLY26 |
| B | SER27 |
| B | GLN28 |
| B | ILE47 |
| B | ARG48 |
| B | SER52 |
| B | LEU79 |
| B | LEU80 |
| B | PRO81 |
| B | ASP82 |
| B | GLN85 |
| B | ALA106 |
| B | HIS107 |
| B | PRO132 |
| B | GLY133 |
| B | E9G401 |
| B | E9J402 |
| B | HOH527 |
| B | HOH532 |
| B | HOH558 |
| B | HOH560 |
| B | HOH563 |
| B | HOH568 |
| B | HOH597 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD2 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD3 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD4 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD5 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD6 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AD9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE1 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE2 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE3 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE4 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE5 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE6 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AE9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF1 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF2 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF3 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF4 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF5 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF6 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G A 404 and E9J A 405 |
| Chain | Residue |
| A | ASP190 |
| A | GLU194 |
| A | LEU198 |
| A | CYS199 |
| A | MG401 |
| A | MG402 |
| A | NAP403 |
| A | HOH501 |
| A | HOH524 |
| A | HOH551 |
| A | HOH571 |
| A | HOH601 |
| B | GLU230 |
| B | ILE234 |
| B | ILE250 |
| B | SER251 |
| B | ALA254 |
| site_id | AF9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG1 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG2 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG3 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG4 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG5 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG6 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AG9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH1 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH2 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH3 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH4 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH5 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH6 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AH9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI1 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI2 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI3 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI4 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI5 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI6 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| site_id | AI7 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI8 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
| site_id | AI9 |
| Number of Residues | 17 |
| Details | binding site for residues E9G B 401 and E9J B 402 |
| Chain | Residue |
| A | GLU230 |
| A | LEU233 |
| A | LEU237 |
| A | ILE250 |
| A | SER251 |
| A | ALA254 |
| B | PRO132 |
| B | ASP190 |
| B | GLU194 |
| B | MG403 |
| B | MG404 |
| B | NAP405 |
| B | HOH501 |
| B | HOH521 |
| B | HOH551 |
| B | HOH597 |
| B | HOH598 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00435","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 145 |
| Details | Domain: {"description":"KARI C-terminal knotted","evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
