2LUT
 
 | | NMR solution structure of midkine-a | | 分子名称: | Midkine-related growth factor | | 著者 | Lim, J, Yang, D, Meng, D. | | 登録日 | 2012-06-21 | | 公開日 | 2013-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Functional Characterization of Two Zebrafish Midkine Proteins Reveals Importance of the Conserved Hinge for Heparin Binding and Embryogenesis
To be Published
|
|
7MSV
 | |
4KI8
 | | Crystal structure of a GroEL-ADP complex in the relaxed allosteric state | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | 著者 | Fei, X, Yang, D, LaRonde-LeBlanc, N, Lorimer, G.H. | | 登録日 | 2013-05-01 | | 公開日 | 2013-07-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.722 Å) | | 主引用文献 | Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 A resolution.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
2ML7
 | | Ginsentides: Characterization, Structure and Application of a New Class of Highly Stable Cystine Knot Peptides in Ginseng | | 分子名称: | Specific abundant protein 3 | | 著者 | Wang, S, Nguyen, K, Luo, S, Tam, J, Yang, D. | | 登録日 | 2014-02-20 | | 公開日 | 2015-03-04 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ginsentides: Characterization, Structure and Application of a New Class of Highly Stable Cystine Knot Peptides in Ginseng
To be Published
|
|
2LYI
 | |
2M6Z
 | |
7MYO
 | | Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719 | | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. | | 登録日 | 2021-05-21 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7MYN
 | | Cryo-EM Structure of p110alpha in complex with p85alpha | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. | | 登録日 | 2021-05-21 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
2F8U
 | | G-quadruplex structure formed in human Bcl-2 promoter, hybrid form | | 分子名称: | 5'-D(*GP*GP*GP*CP*GP*CP*GP*GP*GP*AP*GP*GP*AP*AP*TP*TP*GP*GP*GP*CP*GP*GP*G)-3' | | 著者 | Dai, J, Chen, D, Carver, M, Yang, D. | | 登録日 | 2005-12-03 | | 公開日 | 2006-11-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.
Nucleic Acids Res., 34, 2006
|
|
1EZO
 | | GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN | | 分子名称: | MALTOSE-BINDING PERIPLASMIC PROTEIN | | 著者 | Mueller, G.A, Choy, W.Y, Yang, D, Forman-Kay, J.D, Venters, R.A, Kay, L.E. | | 登録日 | 2000-05-11 | | 公開日 | 2001-05-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
J.Mol.Biol., 300, 2000
|
|
1EZP
 | | GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN USING PEPTIDE ORIENTATIONS FROM DIPOLAR COUPLINGS | | 分子名称: | MALTODEXTRIN BINDING PERIPLASMIC PROTEIN | | 著者 | Mueller, G.A, Choy, W.Y, Yang, D, Forman-Kay, J.D, Venters, R.A, Kay, L.E. | | 登録日 | 2000-05-11 | | 公開日 | 2001-05-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
J.Mol.Biol., 300, 2000
|
|
8Z1E
 | | A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | | 分子名称: | Uncharacterized protein UL78 | | 著者 | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | | 登録日 | 2024-04-11 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM.
Cell Discov, 10, 2024
|
|
7N7E
 | |
7N7D
 | |
6VRH
 | | Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | | 著者 | Coleman, J.A, Navratna, V, Yang, D. | | 登録日 | 2020-02-07 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-09-23 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
|
|
6VRK
 | | Cryo-EM structure of the wild-type human serotonin transporter complexed with Br-paroxetine and 8B6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | | 著者 | Coleman, J.A, Navratna, V, Yang, D. | | 登録日 | 2020-02-07 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-09-23 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
|
|
6W2B
 | | Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, ... | | 著者 | Coleman, J.A, Navratna, V, Yang, D. | | 登録日 | 2020-03-05 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (4.7 Å) | | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
|
|
6VRL
 | | Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | | 著者 | Coleman, J.A, Navratna, V, Yang, D. | | 登録日 | 2020-02-07 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-09-23 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
|
|
6W2C
 | | Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site | | 分子名称: | 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, I-paroxetine, ... | | 著者 | Coleman, J.A, Navratna, V, Yang, D. | | 登録日 | 2020-03-05 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (6.3 Å) | | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
|
|
6V0L
 | | PDGFR-b Promoter Forms a G-Vacancy Quadruplex that Can be Complemented by dGMP: Molecular Structure and Recognition of Guanine Derivatives and Metabolites | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*(3D1)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*A)-3') | | 著者 | Wang, K.B, Dickerhoff, J, Wu, G, Yang, D. | | 登録日 | 2019-11-18 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | PDGFR-beta Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs.
J.Am.Chem.Soc., 142, 2020
|
|
8GUB
 | | Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719 | | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-09-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8GUD
 | | Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719 | | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-09-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8GUA
 | | Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719 | | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-09-11 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8DCP
 | | PI 3-kinase alpha with nanobody 3-126 | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Hart, J.R, Liu, X, Pan, C, Liang, A, Ueno, L, Xu, Y, Quezada, A, Zou, X, Yang, S, Zhou, Q, Schoonooghe, S, Hassanzadeh-Ghassabeh, G, Xia, T, Shui, W, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2022-06-17 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
1S52
 | | Thr24Val Bacteriorhodopsin | | 分子名称: | RETINAL, bacteriorhodopsin | | 著者 | Yohannan, S, Faham, S, Yang, D, Grosfeld, D, Chamberlain, A.K, Bowie, J.U. | | 登録日 | 2004-01-19 | | 公開日 | 2004-03-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A C(alpha)-H.O Hydrogen Bond in a Membrane Protein Is Not Stabilizing
J.Am.Chem.Soc., 126, 2004
|
|
