6W2C

Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site

Summary for 6W2C

Entry DOI	10.2210/pdb6w2c/pdb
Descriptor	Sodium-dependent serotonin transporter, 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, ... (4 entities in total)
Functional Keywords	antidepressant, complex, transporter, antibody, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	110712.90
Authors	Coleman, J.A.,Navratna, V.,Yang, D. (deposition date: 2020-03-05, release date: 2020-03-25, Last modification date: 2023-10-18)
Primary citation	Coleman, J.A.,Navratna, V.,Antermite, D.,Yang, D.,Bull, J.A.,Gouaux, E. Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9:-, 2020 Cited by PubMed: 32618269 DOI: 10.7554/eLife.56427 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (6.3 Å)

Structure validation