6W2C
Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 549 | 61703.8 | 1 | UniProt (P31645) Pfam (PF00209) | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B (B) | 8B6 heavy chain antibody fragment | polymer | 229 | 24853.6 | 1 | Mus musculus (Mouse) | ||
| 3 | C (C) | 8B6 light chain antibody fragment | polymer | 214 | 23718.2 | 1 | Mus musculus (Mouse) | ||
| 4 | D (A) | I-paroxetine | non-polymer | 437.3 | 1 | Chemie (RFY) |
Sequence modifications
A: 76 - 618 (UniProt: P31645)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
| Ser 75 | - | expression tag |
| Ala 110 | Tyr 110 | conflict |
| Ala 291 | Ile 291 | conflict |
| Ala 554 | Cys 554 | conflict |
| Ala 580 | Cys 580 | conflict |
| Leu 619 | - | expression tag |
| Val 620 | - | expression tag |
| Pro 621 | - | expression tag |
| Arg 622 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 110275.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 437.3 | |
| All* | Total formula weight | 110712.9 |
