6W2C
Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue RFY A 705 |
| Chain | Residue |
| A | TYR95 |
| A | THR497 |
| A | VAL501 |
| A | ALA96 |
| A | ASP98 |
| A | ILE172 |
| A | PHE335 |
| A | SER438 |
| A | THR439 |
| A | GLY442 |
| A | LEU443 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| C | TYR212-HIS218 |
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYicaqNGGGaF |
| Chain | Residue | Details |
| A | TRP103-PHE117 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLisSFTdqLPWtsCknswNT |
| Chain | Residue | Details |
| A | TYR186-THR206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | PHE88-ASN112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 158 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLY113-GLY115 | |
| A | LEU187-SER252 | |
| A | ARG298-GLY324 | |
| A | THR381-THR421 | |
| A | GLY484-GLU494 | |
| A | SER559-SER574 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ALA116-MET135 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 81 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | GLU136-GLY160 | |
| A | LYS272-SER277 | |
| A | ALA348-ASP360 | |
| A | GLU444-GLU463 | |
| A | GLY517-ARG538 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ILE161-TYR186 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | TRP253-TRP271 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | GLY278-VAL297 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | VAL325-PHE347 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ALA361-PHE380 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | PHE422-LEU443 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ARG464-PHE483 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | TYR495-TYR516 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ILE539-MET558 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ILE575-TYR595 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6, ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
| Chain | Residue | Details |
| A | GLY94 | |
| A | VAL97 | |
| A | ASP437 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000305|PubMed:27049939, ECO:0000312|PDB:7LIA, ECO:0007744|PDB:5I6X |
| Chain | Residue | Details |
| A | ALA96 | |
| A | SER336 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7MGW |
| Chain | Residue | Details |
| A | ASP98 | |
| A | GLU494 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27049939, ECO:0007744|PDB:5I6X |
| Chain | Residue | Details |
| A | ASN101 | |
| A | ASN368 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7K4Y6 |
| Chain | Residue | Details |
| A | LEU434 | |
| A | SER438 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA, ECO:0000312|PDB:7MGW |
| Chain | Residue | Details |
| A | THR439 | |
| A | PHE556 | |
| A | SER559 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34851672, ECO:0000312|PDB:7LIA |
| Chain | Residue | Details |
| A | TYR495 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21992875 |
| Chain | Residue | Details |
| A | TYR142 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKG => ECO:0000269|PubMed:17913921 |
| Chain | Residue | Details |
| A | THR276 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27049939 |
| Chain | Residue | Details |
| A | ASN208 | |
| A | ASN217 |
