9UWD
 
 | | Cryo-EM structure of inactive-DP1 | | 分子名称: | Prostaglandin D2 receptor,Soluble cytochrome b562 | | 著者 | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | 登録日 | 2025-05-12 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1.
Proc.Natl.Acad.Sci.USA, 122, 2025
|
|
9M1H
 | | Cryo-EM structure of PGE2-EP1-Gq complex | | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Meng, X, Xu, Y, Xu, H.E. | | 登録日 | 2025-02-26 | | 公開日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Structural Insights into the Activation of Human Prostaglandin E2 Receptor EP1 Subtype by Prostaglandin E2
To Be Published
|
|
1G1U
 | | THE 2.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN IN TETRAMER IN THE ABSENCE OF LIGAND | | 分子名称: | RETINOIC ACID RECEPTOR RXR-ALPHA | | 著者 | Gampe Jr, R.T, Montana, V.G, Lambert, M.H, Wisely, G.B, Milburn, M.V, Xu, H.E. | | 登録日 | 2000-10-13 | | 公開日 | 2001-04-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Genes Dev., 14, 2000
|
|
1G5Y
 | | THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER. | | 分子名称: | RETINOIC ACID, RETINOIC ACID RECEPTOR RXR-ALPHA | | 著者 | Gampe Jr, R.T, Montana, V.G, Lambert, M.H, Wisely, G.B, Milburn, M.V, Xu, H.E. | | 登録日 | 2000-11-02 | | 公開日 | 2001-05-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Genes Dev., 14, 2000
|
|
7LJC
 | | Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein | | 分子名称: | (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, ... | | 著者 | Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. | | 登録日 | 2021-01-28 | | 公開日 | 2021-03-03 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Cell Res., 31, 2021
|
|
7LJD
 | | Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein | | 分子名称: | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... | | 著者 | Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E. | | 登録日 | 2021-01-28 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Cell Res., 31, 2021
|
|
5JA5
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A and L130A mutant in complex with rice D53 repressor EAR peptide motif | | 分子名称: | Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION | | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | 登録日 | 2016-04-12 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
|
|
5JHP
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L179A and I195A mutant in complex with rice D53 repressor EAR peptide motif | | 分子名称: | Protein TPR1, The rice D53 EAR peptide (794-808) | | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | 登録日 | 2016-04-21 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
|
|
5J9K
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) in complex with rice D53 repressor EAR peptide motif | | 分子名称: | Protein TPR1, ZINC ION, rice D53 peptide 794-808 | | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | 登録日 | 2016-04-10 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
|
|
5JGC
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A, L130A, L179A and I195A mutant | | 分子名称: | Protein TPR1, ZINC ION | | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | 登録日 | 2016-04-20 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
|
|
9JE0
 | | Human URAT1 bound to benzbromarone | | 分子名称: | Solute carrier family 22 member 12, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs.
Cell Discov, 11, 2025
|
|
9JDV
 | | Human URAT1 bound with Uric acid | | 分子名称: | Solute carrier family 22 member 12, URIC ACID | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs.
Cell Discov, 11, 2025
|
|
9JDZ
 | | Human URAT1 bound to lesinurad | | 分子名称: | Solute carrier family 22 member 12, lesinurad | | 著者 | Wu, C, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs.
Cell Discov, 11, 2025
|
|
9JDY
 | | Human URAT1 bound with verinurad | | 分子名称: | Solute carrier family 22 member 12, verinurad | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs.
Cell Discov, 11, 2025
|
|
9JE1
 | | Human URAT1 bound to dotinurad | | 分子名称: | Solute carrier family 22 member 12, dotinurad | | 著者 | Wu, C, Zhang, C, Jin, S, Wang, J.J, Dai, A, Jiang, Y, Yang, D, Xu, H.E. | | 登録日 | 2024-09-01 | | 公開日 | 2024-10-16 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs.
Cell Discov, 11, 2025
|
|
6VN7
 | | Cryo-EM structure of an activated VIP1 receptor-G protein complex | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. | | 登録日 | 2020-01-29 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.
Nat Commun, 11, 2020
|
|
6UH3
 | | Crystal structure of bacterial heliorhodopsin 48C12 | | 分子名称: | DI(HYDROXYETHYL)ETHER, Heliorhodopsin, PALMITIC ACID, ... | | 著者 | Lu, Y, Zhou, X.E, Gao, X, Xia, R, Xu, Z, Wang, N, Leng, Y, Melcher, K, Xu, H.E, He, Y. | | 登録日 | 2019-09-26 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of heliorhodopsin 48C12.
Cell Res., 30, 2020
|
|
5TO7
 | | Structure of the TPR oligomerization domain | | 分子名称: | Nucleoprotein TPR | | 著者 | Pal, K, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | | 登録日 | 2016-10-16 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
|
|
5TO5
 | | Structure of the TPR oligomerization domain | | 分子名称: | Nucleoprotein TPR | | 著者 | Pal, K, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | | 登録日 | 2016-10-16 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
|
|
5TO6
 | | Structure of the TPR oligomerization domain | | 分子名称: | Nucleoprotein TPR | | 著者 | Pal, K, Bandyopadhyay, A, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | | 登録日 | 2016-10-16 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
|
|
5TVB
 | | Structure of the TPR oligomerization domain | | 分子名称: | Nucleoprotein TPR | | 著者 | Pal, K, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | | 登録日 | 2016-11-08 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
|
|
9U4W
 | | cryo-EM structure of pig GnRHR bound with mammal GnRH | | 分子名称: | Beta-2 adrenergic receptor,Gonadotropin-releasing hormone receptor, Gonadoliberin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shen, S, Xu, H.E. | | 登録日 | 2025-03-20 | | 公開日 | 2025-06-11 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Cryo-EM structures of GnRHR: Foundations for next-generation therapeutics.
Proc.Natl.Acad.Sci.USA, 122, 2025
|
|
9U4Y
 | | cryo-EM structure of Xenopus laevis GnRHR bound with mammal GnRH | | 分子名称: | Beta-2 adrenergic receptor,Gonadotropin-releasing hormone receptor, Gonadoliberin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shen, S, Xu, H.E. | | 登録日 | 2025-03-20 | | 公開日 | 2025-06-11 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | | 主引用文献 | Cryo-EM structures of GnRHR: Foundations for next-generation therapeutics.
Proc.Natl.Acad.Sci.USA, 122, 2025
|
|
9UY3
 | | Anamorelin bound growth hormone secretagogue receptor in complex with Gq | | 分子名称: | 2-azanyl-N-[(2R)-1-[(3S)-3-[dimethylamino(methyl)carbamoyl]-3-(phenylmethyl)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]-2-methyl-propanamide, CHOLESTEROL, Engineered G-alpha-q subunit, ... | | 著者 | Wang, R, Sun, J, Liu, H, Guo, S, Zhang, Y, Hu, W, Wang, J, Liu, H, Zhuang, Y, Jiang, Y, Xie, X, Xu, H.E, Wang, Y. | | 登録日 | 2025-05-14 | | 公開日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | | 主引用文献 | Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor.
Acta Pharmacol.Sin., 2025
|
|
8ZT1
 | |
