5TVB

Structure of the TPR oligomerization domain

Summary for 5TVB

DescriptorNucleoprotein TPR (2 entities in total)
Functional Keywordsreceptor tyrosine kinase, oncogenic fusion kinases, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  P12270
Total number of polymer chains2
Total molecular weight33813.29
Authors
Pal, K.,Xu, Q.,Zhou, X.E.,Melcher, K.,Xu, H.E. (deposition date: 2016-11-08, release date: 2017-09-20, Last modification date: 2017-11-01)
Primary citation
Pal, K.,Bandyopadhyay, A.,Zhou, X.E.,Xu, Q.,Marciano, D.P.,Brunzelle, J.S.,Yerrum, S.,Griffin, P.R.,Vande Woude, G.,Melcher, K.,Xu, H.E.
Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25:867-877.e3, 2017
PubMed: 28528776 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2017.04.015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.302300.4%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5tvb
no rotation
Molmil generated image of 5tvb
rotated about x axis by 90°
Molmil generated image of 5tvb
rotated about y axis by 90°