8PJN
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![BU of 8pjn by Molmil](/molmil-images/mine/8pjn) | Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin | 分子名称: | E3 ubiquitin-protein transferase MAEA, E3 ubiquitin-protein transferase RMND5A, Ubiquitin, ... | 著者 | Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A. | 登録日 | 2023-06-23 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Mol.Cell, 84, 2024
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8PD0
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![BU of 8pd0 by Molmil](/molmil-images/mine/8pd0) | cryo-EM structure of Doa10 in MSP1E3D1 | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ERAD-associated E3 ubiquitin-protein ligase DOA10 | 著者 | Botsch, J.J, Braeuning, B, Schulman, B.A. | 登録日 | 2023-06-11 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15, 2024
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8PDA
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![BU of 8pda by Molmil](/molmil-images/mine/8pda) | cryo-EM structure of Doa10 with RING domain in MSP1E3D1 | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ERAD-associated E3 ubiquitin-protein ligase DOA10 | 著者 | Botsch, J.J, Braeuning, B, Schulman, B.A. | 登録日 | 2023-06-12 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15, 2024
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5L9U
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![BU of 5l9u by Molmil](/molmil-images/mine/5l9u) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | 登録日 | 2016-06-11 | 公開日 | 2016-09-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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5L9T
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![BU of 5l9t by Molmil](/molmil-images/mine/5l9t) | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | 著者 | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | 登録日 | 2016-06-11 | 公開日 | 2016-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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4RG6
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![BU of 4rg6 by Molmil](/molmil-images/mine/4rg6) | Crystal structure of APC3-APC16 complex | 分子名称: | Anaphase-promoting complex subunit 16, Cell division cycle protein 27 homolog | 著者 | Yamaguchi, M, Yu, S, Miller, D.J, Schulman, B.A. | 登録日 | 2014-09-29 | 公開日 | 2014-12-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of an APC3-APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome. J.Mol.Biol., 427, 2015
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4RG9
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![BU of 4rg9 by Molmil](/molmil-images/mine/4rg9) | Crystal structure of APC3-APC16 complex (Selenomethionine Derivative) | 分子名称: | Anaphase-promoting complex subunit 16, Cell division cycle protein 27 homolog | 著者 | Yamaguchi, M, Yu, S, Miller, D.J, Schulman, B.A. | 登録日 | 2014-09-29 | 公開日 | 2014-12-24 | 最終更新日 | 2017-08-02 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structure of an APC3-APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome. J.Mol.Biol., 427, 2015
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7ONI
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![BU of 7oni by Molmil](/molmil-images/mine/7oni) | Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* | 分子名称: | Cullin-5, E3 ubiquitin-protein ligase ARIH2, NEDD8, ... | 著者 | Kostrhon, S.P, prabu, J.R, Schulman, B.A. | 登録日 | 2021-05-25 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nat.Chem.Biol., 17, 2021
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7Z8B
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![BU of 7z8b by Molmil](/molmil-images/mine/7z8b) | |
7ZBZ
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![BU of 7zbz by Molmil](/molmil-images/mine/7zbz) | |
7Z8R
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![BU of 7z8r by Molmil](/molmil-images/mine/7z8r) | CAND1-CUL1-RBX1 | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Baek, K, Schulman, B.A. | 登録日 | 2022-03-18 | 公開日 | 2023-04-19 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
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7Z8T
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![BU of 7z8t by Molmil](/molmil-images/mine/7z8t) | CAND1-SCF-SKP2 CAND1 engaged SCF rocked | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Baek, K, Schulman, B.A. | 登録日 | 2022-03-18 | 公開日 | 2023-04-19 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
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7Z8V
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![BU of 7z8v by Molmil](/molmil-images/mine/7z8v) | |
7ZBW
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![BU of 7zbw by Molmil](/molmil-images/mine/7zbw) | CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Baek, K, Schulman, B.A. | 登録日 | 2022-03-24 | 公開日 | 2023-04-19 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
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6BG3
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![BU of 6bg3 by Molmil](/molmil-images/mine/6bg3) | Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1 | 分子名称: | Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | 登録日 | 2017-10-27 | 公開日 | 2018-09-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61, 2018
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6BG5
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![BU of 6bg5 by Molmil](/molmil-images/mine/6bg5) | Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1 | 分子名称: | Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | 登録日 | 2017-10-27 | 公開日 | 2018-09-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61, 2018
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6WY6
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![BU of 6wy6 by Molmil](/molmil-images/mine/6wy6) | Crystal structure of S. cerevisiae Atg8 in complex with Ede1 (1220-1247) | 分子名称: | Autophagy-related protein 8, EH domain-containing and endocytosis protein 1 | 著者 | Zheng, Y, Wilfling, F, Baumeister, W, Schulman, B.A. | 登録日 | 2020-05-12 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.773 Å) | 主引用文献 | A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Mol.Cell, 80, 2020
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6SWY
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![BU of 6swy by Molmil](/molmil-images/mine/6swy) | Structure of active GID E3 ubiquitin ligase complex minus Gid2 and delta Gid9 RING domain | 分子名称: | Glucose-induced degradation protein 8, Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10,Protein FYV10, Vacuolar import and degradation protein 24, ... | 著者 | Qiao, S, Prabu, J.R, Schulman, B.A. | 登録日 | 2019-09-24 | 公開日 | 2019-11-20 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly Mol.Cell, 77, 2020
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6TTU
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![BU of 6ttu by Molmil](/molmil-images/mine/6ttu) | Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 | 分子名称: | CYS-LYS-LYS-ALA-ARG-HIS-ASP-SEP-GLY, Cullin-1, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Baek, K, Prabu, J.R, Schulman, B.A. | 登録日 | 2019-12-30 | 公開日 | 2020-02-12 | 最終更新日 | 2020-03-04 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature, 578, 2020
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8EBM
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![BU of 8ebm by Molmil](/molmil-images/mine/8ebm) | |
8EBN
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![BU of 8ebn by Molmil](/molmil-images/mine/8ebn) | |
8EBL
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![BU of 8ebl by Molmil](/molmil-images/mine/8ebl) | |
7NS3
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![BU of 7ns3 by Molmil](/molmil-images/mine/7ns3) | Substrate receptor scaffolding module of yeast Chelator-GID SR4 E3 ubiquitin ligase bound to Fbp1 substrate | 分子名称: | BJ4_G0018240.mRNA.1.CDS.1, Fructose-bisphosphatase, Glucose-induced degradation protein 8, ... | 著者 | Sherpa, D, Chrustowicz, J, Prabu, J.R, Schulman, B.A. | 登録日 | 2021-03-05 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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7NSB
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![BU of 7nsb by Molmil](/molmil-images/mine/7nsb) | Supramolecular assembly module of yeast Chelator-GID SR4 E3 ubiquitin ligase | 分子名称: | Glucose-induced degradation protein 7, Glucose-induced degradation protein 8, Vacuolar import and degradation protein 30 | 著者 | Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. | 登録日 | 2021-03-05 | 公開日 | 2021-05-05 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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7NS5
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![BU of 7ns5 by Molmil](/molmil-images/mine/7ns5) | Structure of yeast Fbp1 (Fructose-1,6-bisphosphatase 1) | 分子名称: | Fructose-1,6-bisphosphatase, MAGNESIUM ION, PHOSPHATE ION | 著者 | Sherpa, D, Chrustowicz, J, Prabu, J.R, Schulman, B.A. | 登録日 | 2021-03-05 | 公開日 | 2021-05-05 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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