5TP0
 
 | | Human mesotrypsin in complex with diminazene | | 分子名称: | BERENIL, CALCIUM ION, SULFATE ION, ... | | 著者 | Kayode, O, Soares, A, Radisky, E.S. | | 登録日 | 2016-10-19 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Small molecule inhibitors of mesotrypsin from a structure-based docking screen.
PLoS ONE, 12, 2017
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3V96
 | | Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-1 (TIMP-1) | | 分子名称: | CALCIUM ION, Metalloproteinase inhibitor 1, PHOSPHATE ION, ... | | 著者 | Batra, J, Soares, A.S, Radisky, E.S. | | 登録日 | 2011-12-23 | | 公開日 | 2012-03-28 | | 最終更新日 | 2012-07-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
J.Biol.Chem., 287, 2012
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6BX8
 | | Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | | 分子名称: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | | 著者 | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | | 登録日 | 2017-12-18 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J. Biol. Chem., 294, 2019
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4U32
 | | Human mesotrypsin complexed with HAI-2 Kunitz domain 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... | | 著者 | Wang, R, Soares, A.S, Radisky, E.S. | | 登録日 | 2014-07-18 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
J.Biol.Chem., 289, 2014
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4U30
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3P95
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3P92
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7S7L
 | | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Coban, M, Raeeszadeh-Sarmazdeh, M, Hockla, A, Sankaran, B, Radisky, E.S. | | 登録日 | 2021-09-16 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
J.Biol.Chem., 298, 2022
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7S7M
 | | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) | | 分子名称: | CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ... | | 著者 | Coban, M, Raeeszadeh-Sarmazdeh, M, Sankaran, B, Hockla, A, Radisky, E.S. | | 登録日 | 2021-09-16 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
J.Biol.Chem., 298, 2022
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5NX3
 | | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | | 登録日 | 2017-05-09 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
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5NX1
 | | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | | 登録日 | 2017-05-09 | | 公開日 | 2018-05-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
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4WWY
 | | human cationic trypsin G193R mutant in complex with bovine pancreatic trypsin inhibitor | | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | | 登録日 | 2014-11-12 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates.
J.Biol.Chem., 290, 2015
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4WXV
 | | Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI) | | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | | 登録日 | 2014-11-14 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates.
J.Biol.Chem., 290, 2015
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4ILW
 | | Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2) | | 分子名称: | CALCIUM ION, Metalloproteinase inhibitor 2, Stromelysin-2, ... | | 著者 | Batra, J, Soares, A.S, Radisky, E.S. | | 登録日 | 2013-01-01 | | 公開日 | 2013-11-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes.
Plos One, 8, 2013
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3L3T
 | | Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (APPIR15K) | | 分子名称: | CALCIUM ION, FORMIC ACID, PRSS3 protein, ... | | 著者 | Salameh, M.A, Soares, A.S, Radisky, E.S. | | 登録日 | 2009-12-17 | | 公開日 | 2010-09-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.378 Å) | | 主引用文献 | Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
J.Biol.Chem., 285, 2010
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3L33
 | | Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI) | | 分子名称: | Amyloid beta A4 protein, CALCIUM ION, FORMIC ACID, ... | | 著者 | Salameh, M.A, Soares, A.S, Radisky, E.S. | | 登録日 | 2009-12-16 | | 公開日 | 2010-09-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
J.Biol.Chem., 285, 2010
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5JBT
 | | Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) | | 分子名称: | Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... | | 著者 | Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. | | 登録日 | 2016-04-13 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.
J. Biol. Chem., 291, 2016
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4DG4
 | | Human mesotrypsin-S39Y complexed with bovine pancreatic trypsin inhibitor (BPTI) | | 分子名称: | CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor, ... | | 著者 | Salameh, M.A, Soares, A.S, Radisky, E.S. | | 登録日 | 2012-01-24 | | 公開日 | 2012-09-12 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
Protein Sci., 21, 2012
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2R9P
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4H4F
 | | Crystal structure of human chymotrypsin C (CTRC) bound to inhibitor eglin c from Hirudo medicinalis | | 分子名称: | Chymotrypsin-C, Eglin C, PHOSPHATE ION | | 著者 | Batra, J, Soares, A.S, Radisky, E.S. | | 登録日 | 2012-09-17 | | 公開日 | 2013-02-27 | | 最終更新日 | 2013-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation.
J.Biol.Chem., 288, 2013
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2RA3
 | | Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI) | | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | | 著者 | Salameh, M.A, Soares, A.S, Radisky, E.S. | | 登録日 | 2007-09-14 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
J.Biol.Chem., 283, 2008
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6MAV
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6GFI
 | | Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | | 登録日 | 2018-04-30 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.
Nat Commun, 9, 2018
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6HAR
 | | Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C | | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ... | | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N. | | 登録日 | 2018-08-08 | | 公開日 | 2019-02-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J.Biol.Chem., 294, 2019
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