3L3T

Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (APPIR15K)

Summary for 3L3T

• Entry DOI: 10.2210/pdb3l3t/pdb
• Related: 1ZJD 2R9P
• Descriptor: PRSS3 protein, Protein APP, FORMIC ACID, ... (5 entities in total)
• Functional Keywords: human mesotrypsin, canonical inhibitor, alzheimer's amyloid precursor protein inhibitor, appi, appi-r15k, hydrolase-cell adhesion complex, hydrolase/cell adhesion
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 122784.33

Authors

Salameh, M.A.,Soares, A.S.,Radisky, E.S. (deposition date: 2009-12-17, release date: 2010-09-22, Last modification date: 2011-07-13)

• Primary citation: Salameh, M.A.,Soares, A.S.,Navaneetham, D.,Sinha, D.,Walsh, P.N.,Radisky, E.S.; Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.; J.Biol.Chem., 285:36884-36896, 2010; PubMed: 20861008; DOI: 10.1074/jbc.M110.171348

Experimental method

X-RAY DIFFRACTION (2.378 Å)