3L3T
Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (APPIR15K)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | PRSS3 protein | polymer | 224 | 24257.5 | 4 | UniProt (Q8N2U3) Pfam (PF00089) UniProt (by SIFTS) (P35030) | Homo sapiens (human) | Mesotrypsin |
| 2 | E, F, G, H (E, F, G, H) | Protein APP | polymer | 57 | 6249.0 | 4 | UniProt (C9JHU0) | Homo sapiens (human) | ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR |
| 3 | I, J, K, L, M... (A, B, C) | FORMIC ACID | non-polymer | 46.0 | 13 | Chemie (FMT) | |||
| 4 | P, V, X, Y (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 16 - 246 (UniProt: Q8N2U3)
E, F, G, H: 3 - 59 (UniProt: C9JHU0)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 204 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys 15 | Arg 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 122025.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 758.6 | |
| All* | Total formula weight | 122784.3 |
