3L3T
Human mesotrypsin complexed with amyloid precursor protein inhibitor variant (APPIR15K)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0006508 | biological_process | proteolysis |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0006508 | biological_process | proteolysis |
D | 0004252 | molecular_function | serine-type endopeptidase activity |
D | 0006508 | biological_process | proteolysis |
E | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
G | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
H | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE FMT A 1 |
Chain | Residue |
A | LEU163 |
A | HOH300 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE FMT A 2 |
Chain | Residue |
A | ARG66 |
A | ILE73 |
A | HOH269 |
A | HOH341 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE FMT B 3 |
Chain | Residue |
B | PRO129 |
B | LEU163 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FMT A 4 |
Chain | Residue |
A | TYR234 |
A | VAL235 |
A | ASP236 |
A | TRP237 |
A | ASN233 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE FMT A 247 |
Chain | Residue |
A | ALA221 |
A | TRP221 |
A | LYS222 |
A | HOH327 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE FMT A 248 |
Chain | Residue |
A | SER119 |
A | THR120 |
A | HOH205 |
A | HOH301 |
C | SER122 |
C | GLY203 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE FMT C 247 |
Chain | Residue |
C | PRO129 |
C | LYS230 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE FMT B 10 |
Chain | Residue |
B | SER171 |
B | ASN223 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FMT B 11 |
Chain | Residue |
B | HIS91 |
B | LYS93 |
C | GLY174 |
site_id | BC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE FMT B 12 |
Chain | Residue |
A | THR164 |
B | THR164 |
site_id | BC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE FMT A 13 |
Chain | Residue |
A | GLY219 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 1 |
Chain | Residue |
B | GLU70 |
B | ASN72 |
B | VAL75 |
B | GLU77 |
B | GLU80 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 250 |
Chain | Residue |
A | GLU70 |
A | ASN72 |
A | VAL75 |
A | GLU77 |
A | GLU80 |
A | HOH269 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 3 |
Chain | Residue |
C | GLU70 |
C | ASN72 |
C | VAL75 |
C | GLU77 |
C | GLU80 |
C | HOH289 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA D 4 |
Chain | Residue |
D | GLU70 |
D | ASN72 |
D | VAL75 |
D | GLU80 |
D | HOH267 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
Chain | Residue | Details |
A | VAL53-CYS58 |
site_id | PS00280 |
Number of Residues | 19 |
Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FfyGGCggnrnnFdteeyC |
Chain | Residue | Details |
E | PHE33-CYS51 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU00274, ECO:0000305|PubMed:27810896 |
Chain | Residue | Details |
A | HIS57 | |
D | HIS57 | |
D | ASP102 | |
D | ALA195 | |
A | ASP102 | |
A | ALA195 | |
B | HIS57 | |
B | ASP102 | |
B | ALA195 | |
C | HIS57 | |
C | ASP102 | |
C | ALA195 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0 |
Chain | Residue | Details |
A | GLU70 | |
D | GLU70 | |
D | ASN72 | |
D | VAL75 | |
A | ASN72 | |
A | VAL75 | |
B | GLU70 | |
B | ASN72 | |
B | VAL75 | |
C | GLU70 | |
C | ASN72 | |
C | VAL75 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT |
Chain | Residue | Details |
A | GLU77 | |
B | GLU77 | |
C | GLU77 | |
D | GLU77 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0 |
Chain | Residue | Details |
A | GLU80 | |
B | GLU80 | |
C | GLU80 | |
D | GLU80 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Required for specificity => ECO:0000250 |
Chain | Residue | Details |
A | ASP189 | |
B | ASP189 | |
C | ASP189 | |
D | ASP189 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
Chain | Residue | Details |
A | TYR151 | |
B | TYR151 | |
C | TYR151 | |
D | TYR151 |