6BX8

Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)

Summary for 6BX8

Related6HAR
DescriptorTrypsin-3, Tissue factor pathway inhibitor, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase, hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight136141.38
Authors
Coban, M.,Sankaran, B.,Cohen, I.,Hockla, A.,Papo, N.,Radisky, E.S. (deposition date: 2017-12-18, release date: 2019-02-06, Last modification date: 2019-02-13)
Primary citation
Cohen, I.,Coban, M.,Shahar, A.,Sankaran, B.,Hockla, A.,Lacham, S.,Caulfield, T.R.,Radisky, E.S.,Papo, N.
Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J. Biol. Chem., 2019
PubMed: 30700553 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.007292
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.98 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22120 0.1% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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