6BX8
Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
B | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0006508 | biological_process | proteolysis |
D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
E | 0004252 | molecular_function | serine-type endopeptidase activity |
E | 0006508 | biological_process | proteolysis |
F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
G | 0004252 | molecular_function | serine-type endopeptidase activity |
G | 0006508 | biological_process | proteolysis |
H | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue SO4 B 101 |
Chain | Residue |
A | TYR20 |
A | THR21 |
B | ARG20 |
B | ARG44 |
B | HOH202 |
B | HOH217 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue SO4 C 301 |
Chain | Residue |
D | ARG44 |
D | GLU46 |
D | HOH107 |
D | HOH116 |
D | HOH138 |
C | TYR20 |
C | THR21 |
D | ARG20 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue SO4 F 101 |
Chain | Residue |
E | TYR20 |
E | THR21 |
E | ARG96 |
E | HOH476 |
F | ARG20 |
F | ARG44 |
F | HOH205 |
F | HOH208 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue SO4 H 101 |
Chain | Residue |
G | GLY18 |
G | LYS188 |
H | ARG20 |
H | TYR35 |
H | ARG44 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
Chain | Residue | Details |
A | VAL53-CYS58 |
site_id | PS00280 |
Number of Residues | 19 |
Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FcyGGCegnqnrFesleeC |
Chain | Residue | Details |
B | PHE33-CYS51 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Reactive bond |
Chain | Residue | Details |
B | ARG15 | |
G | HIS57 | |
G | ASP102 | |
G | ALA195 | |
D | ARG15 | |
F | ARG15 | |
H | ARG15 | |
C | ASP102 | |
C | ALA195 | |
E | HIS57 | |
E | ASP102 | |
E | ALA195 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0 |
Chain | Residue | Details |
A | GLU70 | |
G | GLU70 | |
G | ASN72 | |
G | VAL75 | |
A | ASN72 | |
A | VAL75 | |
C | GLU70 | |
C | ASN72 | |
C | VAL75 | |
E | GLU70 | |
E | ASN72 | |
E | VAL75 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT |
Chain | Residue | Details |
A | GLU77 | |
C | GLU77 | |
E | GLU77 | |
G | GLU77 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0 |
Chain | Residue | Details |
A | GLU80 | |
C | GLU80 | |
E | GLU80 | |
G | GLU80 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Required for specificity => ECO:0000250 |
Chain | Residue | Details |
A | ASP189 | |
C | ASP189 | |
E | ASP189 | |
G | ASP189 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Sulfotyrosine => ECO:0000250 |
Chain | Residue | Details |
A | TYR151 | |
C | TYR151 | |
E | TYR151 | |
G | TYR151 |