3P95
Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant (BPTI-K15R/R17D)
Summary for 3P95
Entry DOI | 10.2210/pdb3p95/pdb |
Related | 2R9P |
Descriptor | PRSS3 protein, Pancreatic trypsin inhibitor, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | human mesotrypsin-canonical inhibitor complex, mesotrypsin, trypsin iv, bovine pancreatic trypsin inhibitor, canonical inhibitor, bpti-k15r/r17d, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00974 |
Total number of polymer chains | 2 |
Total formula weight | 30811.01 |
Authors | Salameh, M.A.,Soares, A.S.,Radisky, E.S. (deposition date: 2010-10-15, release date: 2011-08-31, Last modification date: 2023-09-06) |
Primary citation | Salameh, M.A.,Soares, A.S.,Hockla, A.,Radisky, D.C.,Radisky, E.S. The P2' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem.J., 440:95-105, 2011 Cited by PubMed: 21806544DOI: 10.1042/BJ20110788 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2991 Å) |
Structure validation
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