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5T46
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Crystal structure of the human eIF4E-eIF4G complex
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, ...
著者Gruener, S, Peter, D, Weber, R, Wohlbold, L, Chung, M.-Y, Weichenrieder, O, Valkov, E, Igreja, C, Izaurralde, E.
登録日2016-08-29
公開日2016-10-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
Mol.Cell, 64, 2016
4G6J
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BU of 4g6j by Molmil
Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab
分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab
著者Blech, M, Hoerer, S.
登録日2012-07-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013
4G5Z
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Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state
分子名称: canakinumab antibody fragment heavy chain, canakinumab antibody fragment light chain
著者Blech, M, Hoerer, S.
登録日2012-07-18
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013
4G6M
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BU of 4g6m by Molmil
Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
分子名称: Interleukin-1 beta, heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment
著者Blech, M, Hoerer, S.
登録日2012-07-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
J.Mol.Biol., 425, 2013
4G6K
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BU of 4g6k by Molmil
Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state
分子名称: heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment
著者Blech, M, Hoerer, S.
登録日2012-07-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013
4CZY
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BU of 4czy by Molmil
Complex of Neurospora crassa PAN2 (WD40-CS1) with PAN3 (pseudokinase and C-term)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ...
著者Jonas, S, Izaurralde, E, Weichenrieder, O.
登録日2014-04-22
公開日2014-06-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
4D0K
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Complex of Chaetomium thermophilum PAN2 (WD40-CS1) with PAN3 (C-term)
分子名称: A-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3-LIKE PROTEIN
著者Jonas, S, Izaurralde, E, Weichenrieder, O.
登録日2014-04-28
公開日2014-06-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
4CZW
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Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain)
分子名称: PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ZINC ION
著者Christie, M, Izaurralde, E, Weichenrieder, O.
登録日2014-04-22
公開日2014-06-04
最終更新日2014-07-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
4CZX
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Complex of Neurospora crassa PAN2 (WD40) with PAN3 (C-TERM)
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ...
著者Jonas, S, Izaurralde, E, Weichenrieder, O.
登録日2014-04-22
公開日2014-06-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
6FC2
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BU of 6fc2 by Molmil
Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae
分子名称: CALCIUM ION, Eukaryotic translation initiation factor 4E, Protein EAP1
著者Gruener, S, Valkov, E.
登録日2017-12-20
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Nucleic Acids Res., 46, 2018
6FBZ
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Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum in the cap-bound state
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-like protein,Eukaryotic translation initiation factor 4E-like protein, Eukaryotic translation initiation factor 4G
著者Gruener, S, Valkov, E.
登録日2017-12-20
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.496 Å)
主引用文献Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Nucleic Acids Res., 46, 2018
6FC3
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Crystal structure of the eIF4E-p20 complex from Saccharomyces cerevisiae
分子名称: Cap-associated protein CAF20, Eukaryotic translation initiation factor 4E, GLYCEROL, ...
著者Gruener, S, Valkov, E.
登録日2017-12-20
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Nucleic Acids Res., 46, 2018
6FC1
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BU of 6fc1 by Molmil
Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, GLYCEROL, ...
著者Gruener, S, Valkov, E.
登録日2017-12-20
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Nucleic Acids Res., 46, 2018
6FC0
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BU of 6fc0 by Molmil
Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum
分子名称: Eukaryotic translation initiation factor 4E-like protein, Eukaryotic translation initiation factor 4G
著者Gruener, S, Valkov, E.
登録日2017-12-20
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.293 Å)
主引用文献Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Nucleic Acids Res., 46, 2018
4IY6
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BU of 4iy6 by Molmil
Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution
分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ...
著者Krintel, C, Frydenvang, K, Harpsoe, K, Gajhede, M, Kastrup, J.S.
登録日2013-01-28
公開日2013-10-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Acta Crystallogr.,Sect.D, 69, 2013
8QVU
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BU of 8qvu by Molmil
Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex
分子名称: (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Wijaya, A.J, Zollman, D, Farnaby, W, Ciulli, A.
登録日2023-10-18
公開日2023-12-06
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Targeting cancer with small molecule pan-KRAS degraders
Biorxiv, 2023
8QW6
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Crystal Structure of compound 3 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
分子名称: (2S,4R)-1-[(2S)-2-[6-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]hexanoylamino]-3,3-dimethyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Zollman, D, Farnaby, W, Ciulli, A.
登録日2023-10-18
公開日2023-12-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting cancer with small molecule pan-KRAS degraders
Biorxiv, 2023
8QW7
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Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
分子名称: (2S,4R)-1-[(2R)-2-[3-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
著者Zollman, D, Farnaby, W, Ciulli, A.
登録日2023-10-18
公開日2023-12-06
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Targeting cancer with small molecule pan-KRAS degraders
Biorxiv, 2023
4IY5
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Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution
分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ...
著者Krintel, C, Frydenvang, K, Harpsoe, K, Gajhede, M, Kastrup, J.S.
登録日2013-01-28
公開日2013-10-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Acta Crystallogr.,Sect.D, 69, 2013
8QUG
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KRAS-G12C in Complex with Compound 1
分子名称: (4S)-2-azanyl-4-methyl-4-[3-[2-[(2S)-2-methyl-1,4-diazepan-1-yl]pyrimidin-4-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者Fischer, G, Kratochvil, B.
登録日2023-10-16
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Targeting cancer with small molecule pan-KRAS degraders
Biorxiv, 2023
8Q91
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Structure of the human 20S U5 snRNP core
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Schneider, S, Galej, W.P.
登録日2023-08-19
公開日2024-03-27
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
8RC0
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Structure of the human 20S U5 snRNP
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Schneider, S, Galej, W.P.
登録日2023-12-05
公開日2024-03-27
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
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