4IY6

Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution

Summary for 4IY6

• Entry DOI: 10.2210/pdb4iy6/pdb
• Related: 2AL4 2AL5 3TDJ 3TDK 4IY5
• Descriptor: Glutamate receptor 2, [(3R)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone, [(3S)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone, ... (7 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, glua2 s1s2j-l483y-n754s, me-cx516, allosteric modulation, membrane protein
• Biological source: Rattus norvegicus (rat, brown rat, rats); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 1
• Total formula weight: 30441.97

Authors

Krintel, C.,Frydenvang, K.,Harpsoe, K.,Gajhede, M.,Kastrup, J.S. (deposition date: 2013-01-28, release date: 2013-10-09, Last modification date: 2023-11-08)

• Primary citation: Krintel, C.,Harpse, K.,Zachariassen, L.G.,Peters, D.,Frydenvang, K.,Pickering, D.S.,Gajhede, M.,Kastrup, J.S.; Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain; Acta Crystallogr.,Sect.D, 69:1645-1652, 2013; PubMed: 23999288; DOI: 10.1107/S0907444913011839

Experimental method

X-RAY DIFFRACTION (1.72 Å)