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4IY6

Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE MQR A 301
ChainResidue
APRO105
ASER242
AHOH471
APRO105
AMET107
ASER108
ASER108
ASER217
ASER217
ALYS218
ALYS218

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MQS A 302
ChainResidue
AHIS23
AGLU24
ALYS129
AGLN130
ATHR131
AILE133
ATYR161
AHOH487
AHOH535

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MQS A 303
ChainResidue
ATYR80
ALYS116
ALYS117
AGLY118
ATHR119
APRO120
ALYS185
AGLY186
ALYS187
AHOH513

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GLU A 304
ChainResidue
ATYR61
APRO89
ALEU90
ATHR91
AARG96
AGLY141
ASER142
ATHR143
AGLU193
ATYR220
AHOH401
AHOH430
AHOH457

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 305
ChainResidue
AARG148
ATRP159
AARG163
AHOH540

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 306
ChainResidue
ASER140
ALYS144
AARG148
AHOH459
AHOH478
AHOH649

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 307
ChainResidue
ALYS82
ALYS116
AHOH586
AHOH726
AHOH743

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
APRO89
ATHR91
AARG96
ASER142
ATHR143
AGLU193

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
AARG64
AARG148
ALYS240

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AILE121

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER150

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER184

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN3

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PDB entries from 2024-07-10

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