4IY6

Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamate receptor 2	polymer	263	29244.7	1	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Rattus norvegicus (rat brown rat rats)	GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
2	A	[(3R)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone	non-polymer		255.3	1	Chemie (MQR)
3	A	[(3S)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone	non-polymer		255.3	2	Chemie (MQS)
4	A	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7		water	water		18.0	386	Chemie (HOH)

Sequence modifications

A: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag
Tyr 94	Leu 504	engineered mutation

A: 120 - 263 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker
Ser 242	Asn 775	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29244.7
Non-Polymers*	Number of molecules	7
	Total formula weight	1197.3
All*	Total formula weight	30442.0

*Water molecules are not included.