4IY6
Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor 2 | polymer | 263 | 29244.7 | 1 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (rat brown rat rats) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
| 2 | B (A) | [(3R)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone | non-polymer | 255.3 | 1 | Chemie (MQR) | |||
| 3 | C, D (A) | [(3S)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone | non-polymer | 255.3 | 2 | Chemie (MQS) | |||
| 4 | E (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G, H (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | I (A) | water | water | 18.0 | 386 | Chemie (HOH) |
Sequence modifications
A: 3 - 117 (UniProt: P19491)
A: 120 - 263 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Tyr 94 | Leu 504 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29244.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1197.3 | |
| All* | Total formula weight | 30442.0 |
