4G5Z

Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state

Summary for 4G5Z

Entry DOI	10.2210/pdb4g5z/pdb
Related	4G6J 4G6K 4G6M
Descriptor	canakinumab antibody fragment heavy chain, canakinumab antibody fragment light chain (3 entities in total)
Functional Keywords	immunoglobulin fold, antibody, immunoglobulin, interleukine-1beta binding, cytokine, blood system, immune system
Biological source	homo sapiens (humans) More
Total number of polymer chains	2
Total formula weight	46498.80
Authors	Blech, M.,Hoerer, S. (deposition date: 2012-07-18, release date: 2012-12-19, Last modification date: 2023-09-13)
Primary citation	Blech, M.,Peter, D.,Fischer, P.,Bauer, M.M.,Hafner, M.,Zeeb, M.,Nar, H. One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425:94-111, 2013 Cited by PubMed: 23041424 DOI: 10.1016/j.jmb.2012.09.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation