4G6J

Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab

Summary for 4G6J

Entry DOI	10.2210/pdb4g6j/pdb
Related	4G5Z
Descriptor	Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab, ... (4 entities in total)
Functional Keywords	immunglobulin fold, interleukin-1beta binding, immune system
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01584
Total number of polymer chains	3
Total formula weight	64492.43
Authors	Blech, M.,Hoerer, S. (deposition date: 2012-07-19, release date: 2012-12-19, Last modification date: 2023-09-13)
Primary citation	Blech, M.,Peter, D.,Fischer, P.,Bauer, M.M.,Hafner, M.,Zeeb, M.,Nar, H. One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425:94-111, 2013 Cited by PubMed: 23041424 DOI: 10.1016/j.jmb.2012.09.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation