4G6J
Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interleukin-1 beta | polymer | 158 | 17993.6 | 1 | UniProt (P01584) Pfam (PF00340) In PDB | Homo sapiens | IL-1 beta, Catabolin |
2 | H | heavy chain of antibody binding fragment of canakinumab | polymer | 218 | 23349.2 | 1 | Homo sapiens | ||
3 | L | light chain of antibody binding fragment of canakinumab | polymer | 212 | 23149.7 | 1 | Homo sapiens | ||
4 | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
A: 1 - 153 (UniProt: P01584)
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
Leu 154 | - | expression tag |
Val 155 | - | expression tag |
Pro 156 | - | expression tag |
Arg 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 64492.4 | |
All* | Total formula weight | 64492.4 |