4G6J
Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-1 beta | polymer | 158 | 17993.6 | 1 | UniProt (P01584) Pfam (PF00340) | Homo sapiens | IL-1 beta, Catabolin |
| 2 | B (H) | heavy chain of antibody binding fragment of canakinumab | polymer | 218 | 23349.2 | 1 | Homo sapiens | ||
| 3 | C (L) | light chain of antibody binding fragment of canakinumab | polymer | 212 | 23149.7 | 1 | Homo sapiens | ||
| 4 | D, E, F (A, H, L) | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
A: 1 - 153 (UniProt: P01584)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Leu 154 | - | expression tag |
| Val 155 | - | expression tag |
| Pro 156 | - | expression tag |
| Arg 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64492.4 | |
| All* | Total formula weight | 64492.4 |
