5T46

Crystal structure of the human eIF4E-eIF4G complex

Summary for 5T46

Entry DOI	10.2210/pdb5t46/pdb
Descriptor	Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4 gamma 1, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	translation, gene regulation, cap binding protein, 4e-binding protein, translation initiation, eif4f
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm, P-body : P06730
Total number of polymer chains	4
Total formula weight	68480.61
Authors	Gruener, S.,Peter, D.,Weber, R.,Wohlbold, L.,Chung, M.-Y.,Weichenrieder, O.,Valkov, E.,Igreja, C.,Izaurralde, E. (deposition date: 2016-08-29, release date: 2016-10-26, Last modification date: 2024-01-17)
Primary citation	Gruner, S.,Peter, D.,Weber, R.,Wohlbold, L.,Chung, M.Y.,Weichenrieder, O.,Valkov, E.,Igreja, C.,Izaurralde, E. The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol.Cell, 64:467-479, 2016 Cited by PubMed: 27773676 DOI: 10.1016/j.molcel.2016.09.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation