5T46
Crystal structure of the human eIF4E-eIF4G complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Eukaryotic translation initiation factor 4E | polymer | 220 | 25503.7 | 2 | UniProt (P06730) Pfam (PF01652) | Homo sapiens (Human) | eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
| 2 | B, D (B, D) | Eukaryotic translation initiation factor 4 gamma 1 | polymer | 66 | 7876.0 | 2 | UniProt (Q04637) | Homo sapiens (Human) | eIF-4G1,p220 |
| 3 | E, H (A, C) | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 538.2 | 2 | Chemie (MGP) | |||
| 4 | F, G, I, J, K... (A, C) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 5 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 217 (UniProt: P06730)
B, D: 592 - 653 (UniProt: Q04637)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Leu -1 | - | expression tag |
| Glu 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 588 | - | expression tag |
| Pro 589 | - | expression tag |
| His 590 | - | expression tag |
| Met 591 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66759.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1721.1 | |
| All* | Total formula weight | 68480.6 |
