5T46
Crystal structure of the human eIF4E-eIF4G complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Eukaryotic translation initiation factor 4E | polymer | 220 | 25503.7 | 2 | UniProt (P06730) Pfam (PF01652) In PDB | Homo sapiens (Human) | eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
2 | B, D | Eukaryotic translation initiation factor 4 gamma 1 | polymer | 66 | 7876.0 | 2 | UniProt (Q04637) In PDB | Homo sapiens (Human) | eIF-4G1,p220 |
3 | A, C | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 538.2 | 2 | Chemie (MGP) | |||
4 | A, C | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
5 | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 217 (UniProt: P06730)
B, D: 592 - 653 (UniProt: Q04637)
PDB | External Database | Details |
---|---|---|
Met -2 | - | initiating methionine |
Leu -1 | - | expression tag |
Glu 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 588 | - | expression tag |
Pro 589 | - | expression tag |
His 590 | - | expression tag |
Met 591 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 66759.5 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1721.1 | |
All* | Total formula weight | 68480.6 |