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5T46

Crystal structure of the human eIF4E-eIF4G complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000932cellular_componentP-body
A0001662biological_processbehavioral fear response
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0006417biological_processregulation of translation
A0010494cellular_componentcytoplasmic stress granule
A0010507biological_processnegative regulation of autophagy
A0016281cellular_componenteukaryotic translation initiation factor 4F complex
A0016442cellular_componentRISC complex
A0016604cellular_componentnuclear body
A0016607cellular_componentnuclear speck
A0017148biological_processnegative regulation of translation
A0019827biological_processstem cell population maintenance
A0019899molecular_functionenzyme binding
A0030182biological_processneuron differentiation
A0031370molecular_functioneukaryotic initiation factor 4G binding
A0033391cellular_componentchromatoid body
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0045665biological_processnegative regulation of neuron differentiation
A0045931biological_processpositive regulation of mitotic cell cycle
A0048471cellular_componentperinuclear region of cytoplasm
A0051028biological_processmRNA transport
A0051168biological_processnuclear export
A0070062cellular_componentextracellular exosome
A0071549biological_processcellular response to dexamethasone stimulus
A0098794cellular_componentpostsynapse
A0098808molecular_functionmRNA cap binding
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A0140297molecular_functionDNA-binding transcription factor binding
C0000082biological_processG1/S transition of mitotic cell cycle
C0000339molecular_functionRNA cap binding
C0000340molecular_functionRNA 7-methylguanosine cap binding
C0000932cellular_componentP-body
C0001662biological_processbehavioral fear response
C0003723molecular_functionRNA binding
C0003743molecular_functiontranslation initiation factor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006406biological_processmRNA export from nucleus
C0006412biological_processtranslation
C0006413biological_processtranslational initiation
C0006417biological_processregulation of translation
C0010494cellular_componentcytoplasmic stress granule
C0010507biological_processnegative regulation of autophagy
C0016281cellular_componenteukaryotic translation initiation factor 4F complex
C0016442cellular_componentRISC complex
C0016604cellular_componentnuclear body
C0016607cellular_componentnuclear speck
C0017148biological_processnegative regulation of translation
C0019827biological_processstem cell population maintenance
C0019899molecular_functionenzyme binding
C0030182biological_processneuron differentiation
C0031370molecular_functioneukaryotic initiation factor 4G binding
C0033391cellular_componentchromatoid body
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0045665biological_processnegative regulation of neuron differentiation
C0045931biological_processpositive regulation of mitotic cell cycle
C0048471cellular_componentperinuclear region of cytoplasm
C0051028biological_processmRNA transport
C0051168biological_processnuclear export
C0070062cellular_componentextracellular exosome
C0071549biological_processcellular response to dexamethasone stimulus
C0098794cellular_componentpostsynapse
C0098808molecular_functionmRNA cap binding
C0098978cellular_componentglutamatergic synapse
C0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
C0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue MGP A 301
ChainResidue
ATRP56
AHOH431
AHOH442
AHOH462
AHOH482
BGLU608
AMET101
ATRP102
AGLU103
AARG157
ALYS162
ALYS206
AHOH408
AHOH420

site_idAC2
Number of Residues6
Detailsbinding site for residue GOL A 302
ChainResidue
AARG128
APHE129
AGLU132
AARG186
ALEU187
BARG614

site_idAC3
Number of Residues2
Detailsbinding site for residue GOL A 303
ChainResidue
AGLU174
AHOH417

site_idAC4
Number of Residues10
Detailsbinding site for residue MGP C 301
ChainResidue
CTRP56
CMET101
CTRP102
CGLU103
CARG157
CLYS162
CHOH402
CHOH421
CHOH428
CHOH432

site_idAC5
Number of Residues4
Detailsbinding site for residue GOL C 302
ChainResidue
CTYR76
CARG128
CHOH497
CHOH525

site_idAC6
Number of Residues6
Detailsbinding site for residue GOL C 303
ChainResidue
CARG128
CGLU132
CARG186
CLEU187
CGLY188
DARG614

site_idAC7
Number of Residues1
Detailsbinding site for residue GOL C 304
ChainResidue
CLYS184

site_idAC8
Number of Residues4
Detailsbinding site for residue GOL C 305
ChainResidue
CLYS54
CASN59
CHOH463
DGLU608

site_idAC9
Number of Residues8
Detailsbinding site for residue GOL C 306
ChainResidue
ALYS54
AALA58
AARG61
AHOH447
CLEU39
CGLN40
CHOH417
DLYS610

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q6NZJ6
ChainResidueDetails
BLYS602
DLYS602
AARG157
ATHR205
CTRP56
CTRP102
CARG157
CTHR205

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR647
DTHR647

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2
CALA2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR22
CTHR22

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323
ChainResidueDetails
ASER209
CSER209

222624

PDB entries from 2024-07-17

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