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6XY2
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BU of 6xy2 by Molmil
Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Heavy chain, ...
著者Gao, H, Zhou, A.
登録日2020-01-29
公開日2020-12-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody.
Cell Discov, 6, 2020
7YTJ
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BU of 7ytj by Molmil
Cryo-EM structure of VTC complex
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, INOSITOL HEXAKISPHOSPHATE, PHOSPHATE ION, ...
著者Guan, Z.Y, Chen, J, Liu, R.W, Chen, Y.K, Xing, Q, Du, Z.M, Liu, Z.
登録日2022-08-15
公開日2023-02-22
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex.
Nat Commun, 14, 2023
7U5B
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BU of 7u5b by Molmil
Structure of Human KLK5 bound to anti-KLK5 Fab
分子名称: Kallikrein-5, SULFATE ION, anti-KLK5 Fab Heavy Chain, ...
著者Yin, J, Sudhamsu, J.
登録日2022-03-02
公開日2022-12-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.371 Å)
主引用文献Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Sci Transl Med, 14, 2022
7SEG
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BU of 7seg by Molmil
Crystal structure of the complex of CD16A bound by an anti-CD16A Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Kiefer, J.R, Wallweber, H.A, Polson, A.G.
登録日2021-09-30
公開日2021-11-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.156 Å)
主引用文献A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.
Leukemia, 36, 2022
8AG1
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BU of 8ag1 by Molmil
Crystal structure of a novel OX40 antibody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Novel OX40 antibody heavy chain, Novel OX40 antibody light chain, ...
著者Gao, H, Zhou, A.
登録日2022-07-19
公開日2023-07-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.303 Å)
主引用文献Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Biomolecules, 12, 2022
5INW
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BU of 5inw by Molmil
Structure of reaction loop cleaved lamprey angiotensinogen
分子名称: C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION
著者Wei, H, Zhou, A.
登録日2016-03-08
公開日2016-10-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016
6M6E
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BU of 6m6e by Molmil
Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)
分子名称: Fibroblast growth factor 21
著者Zhu, L, Zhao, H, Wang, J.
登録日2020-03-14
公開日2021-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6M6F
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BU of 6m6f by Molmil
Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)
分子名称: Fibroblast growth factor 21
著者Zhu, L, Zhao, H, Wang, J.
登録日2020-03-14
公開日2021-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
5JDR
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BU of 5jdr by Molmil
Structure of PD-L1
分子名称: Programmed cell death 1 ligand 1
著者Zhou, A, Wei, H.
登録日2016-04-17
公開日2017-04-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Cell Discov, 3, 2017
5JDS
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BU of 5jds by Molmil
Crystal structure of PD-L1 complexed with a nanobody at 1.7 Angstron resolution
分子名称: CHLORIDE ION, Nanobody, Programmed cell death 1 ligand 1, ...
著者Zhou, A, Wei, H.
登録日2016-04-17
公開日2017-04-12
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Cell Discov, 3, 2017
5UEL
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BU of 5uel by Molmil
Crystal structure of 354NC102 Fab
分子名称: 354NC102 Fab Heavy Chain, 354NC102 Fab Light Chain, SULFATE ION
著者Sievers, S.A, Gristick, H.B, Bjorkman, P.J.
登録日2017-01-02
公開日2017-02-01
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
5UD9
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BU of 5ud9 by Molmil
Crystal structure of 354BG18 Fab
分子名称: Fab heavy chain, Light chain
著者Scharf, L, Bjorkman, P.J.
登録日2016-12-23
公開日2017-02-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
5UEM
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BU of 5uem by Molmil
Crystal structure of 354NC37 Fab in complex with HIV-1 clade AE strain 93TH057 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 354NC37 Fab Heavy Chain, ...
著者Sievers, S.A, Gristick, H.B, Bjorkman, P.J.
登録日2017-01-02
公開日2018-01-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
7LT2
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BU of 7lt2 by Molmil
Structure of a dsRNA-sensing cGAS-like receptor from the beetle Tribolium castaneum
分子名称: MANGANESE (II) ION, Mab-21 domain-containing protein
著者Slavik, K.M, Morehouse, B.R, Kranzusch, P.J.
登録日2021-02-18
公開日2021-07-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
Nature, 597, 2021
7LT1
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BU of 7lt1 by Molmil
Structure of the cGAS-like receptor human MB21D2
分子名称: Protein MB21D2, SULFATE ION
著者Morehouse, B.R, Slavik, K.M, Kranzusch, P.J.
登録日2021-02-18
公開日2021-07-21
最終更新日2021-09-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
Nature, 597, 2021
7MWY
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BU of 7mwy by Molmil
Structure of the drosophila STING cyclic dinucleotide binding domain
分子名称: STING
著者Slavik, K.M, Ragucci, A.E, Kranzusch, P.J.
登録日2021-05-17
公開日2021-07-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
Nature, 597, 2021
7MWZ
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BU of 7mwz by Molmil
Structure of drosophila STING in complex with 3'2'-cGAMP
分子名称: 3'2'-cGAMP, STING
著者Slavik, K.M, Ragucci, A.E, Kranzusch, P.J.
登録日2021-05-17
公開日2021-07-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
Nature, 597, 2021
4N5T
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BU of 4n5t by Molmil
The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041
分子名称: ATSP-7041 stapled-peptide, Protein Mdm4
著者Graves, B.J, Lukacs, C, Janson, C.A.
登録日2013-10-10
公開日2013-11-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc.Natl.Acad.Sci.USA, 110, 2013
5UUT
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BU of 5uut by Molmil
N-myristoyltransferase 1 (NMT) bound to myristoyl-CoA
分子名称: CITRIC ACID, Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA
著者Goodwin, O, Pegan, S.
登録日2017-02-17
公開日2018-01-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.
Cancer Res., 77, 2017
2R1H
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BU of 2r1h by Molmil
met-Trout IV hemoglobin at pH 6.3
分子名称: 1,2-ETHANEDIOL, Hemoglobin subunit alpha-4, Hemoglobin subunit beta-4, ...
著者Aranda IV, R, Worley, C.E, Richards, M.P, Phillips Jr, G.N.
登録日2007-08-22
公開日2008-09-02
最終更新日2013-01-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
2QSS
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BU of 2qss by Molmil
Bovine hemoglobin at pH 6.3
分子名称: CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ...
著者Aranda IV, R, Richards, M.P, Phillips Jr, G.N.
登録日2007-07-31
公開日2008-09-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
2QSP
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BU of 2qsp by Molmil
Bovine Hemoglobin at pH 5.7
分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE
著者Aranda IV, R, Richards, M.P, Phillips Jr, G.N.
登録日2007-07-31
公開日2008-09-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
8JRV
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BU of 8jrv by Molmil
Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1
分子名称: Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ...
著者Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B.
登録日2023-06-17
公開日2023-08-16
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Tail engagement of arrestin at the glucagon receptor.
Nature, 620, 2023
8JRU
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BU of 8jru by Molmil
Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
分子名称: Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, Nanobody 32, ...
著者Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B.
登録日2023-06-17
公開日2023-08-16
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Tail engagement of arrestin at the glucagon receptor.
Nature, 620, 2023
8IYA
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BU of 8iya by Molmil
Complex of SETDB1-derived peptide bound to UBE2E1
分子名称: Histone-lysine N-methyltransferase SETDB1, SULFATE ION, Ubiquitin-conjugating enzyme E2 E1
著者Du, Y.X, Liu, L.
登録日2023-04-04
公開日2024-01-03
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1.
Nat Commun, 15, 2024

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