6M6F

Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)

Summary for 6M6F

• Entry DOI: 10.2210/pdb6m6f/pdb
• Related: 6M6E
• Descriptor: Fibroblast growth factor 21 (1 entity in total)
• Functional Keywords: disulfide bond mutaion, beta-trefoil conformation, beta-klotho binding, metabolic regulator, hormone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14103.98

Authors

Zhu, L.,Zhao, H.,Wang, J. (deposition date: 2020-03-14, release date: 2021-01-20, Last modification date: 2023-06-14)

• Primary citation: Zhu, L.,Zhao, H.,Liu, J.,Cai, H.,Wu, B.,Liu, Z.,Zhou, S.,Liu, Q.,Li, X.,Bao, B.,Liu, J.,Dai, H.,Wang, J.; Dynamic folding modulation generates FGF21 variant against diabetes.; Embo Rep., 22:e51352-e51352, 2021; PubMed: 33295692; DOI: 10.15252/embr.202051352

Experimental method

SOLUTION NMR