6C54
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![BU of 6c54 by Molmil](/molmil-images/mine/6c54) | Ebola nucleoprotein nucleocapsid-like assembly and the asymmetric unit | 分子名称: | Nucleoprotein | 著者 | Su, Z, Wu, C, Pintilie, G.D, Chiu, W, Amarasinghe, G.K, Leung, D.W. | 登録日 | 2018-01-13 | 公開日 | 2018-03-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell, 172, 2018
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6WX7
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![BU of 6wx7 by Molmil](/molmil-images/mine/6wx7) | SOX2 bound to Importin-alpha 2 | 分子名称: | Importin subunit alpha-1, Transcription factor SOX-2 | 著者 | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | 登録日 | 2020-05-09 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
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6WX8
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![BU of 6wx8 by Molmil](/molmil-images/mine/6wx8) | SOX2 bound to Importin-alpha 3 | 分子名称: | Importin subunit alpha-3, SULFATE ION, Transcription factor SOX-2 | 著者 | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | 登録日 | 2020-05-10 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
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5VJ2
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![BU of 5vj2 by Molmil](/molmil-images/mine/5vj2) | Structure of human respiratory syncytial virus non-structural protein 1 (NS1) | 分子名称: | 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, GLYCEROL, ... | 著者 | Leung, D.W, Borek, D.M, Amarasinghe, G.K. | 登録日 | 2017-04-18 | 公開日 | 2017-07-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nat Microbiol, 2, 2017
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6WX9
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![BU of 6wx9 by Molmil](/molmil-images/mine/6wx9) | SOX2 bound to Importin-alpha 5 | 分子名称: | Importin subunit alpha-5, Transcription factor SOX-2 | 著者 | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | 登録日 | 2020-05-10 | 公開日 | 2020-10-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
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6DKU
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![BU of 6dku by Molmil](/molmil-images/mine/6dku) | Crystal structure of Myotis VP35 mutant of interferon inhibitory domain | 分子名称: | VP35 | 著者 | Liu, H, Ginell, G.M, Keefe, L.J, Leung, D.W, Amarasinghe, G.K. | 登録日 | 2018-05-30 | 公開日 | 2018-07-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes. Cell Rep, 24, 2018
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6E5X
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![BU of 6e5x by Molmil](/molmil-images/mine/6e5x) | Crystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complex | 分子名称: | CALCIUM ION, E3 ubiquitin-protein ligase RBBP6, Minor nucleoprotein VP30 | 著者 | Liu, D, Small, G.I, Leung, D.W, Amarasinghe, G.K. | 登録日 | 2018-07-23 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Cell, 175, 2018
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6OTC
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![BU of 6otc by Molmil](/molmil-images/mine/6otc) | Synthetic Fab bound to Marburg virus VP35 interferon inhibitory domain | 分子名称: | CHLORIDE ION, GLYCEROL, Polymerase cofactor VP35, ... | 著者 | Amatya, P, Chen, G, Borek, D, Sidhu, S.S, Leung, D.W. | 登録日 | 2019-05-02 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody. Acs Infect Dis., 5, 2019
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4GHL
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![BU of 4ghl by Molmil](/molmil-images/mine/4ghl) | Structural Basis for Marburg virus VP35 mediate immune evasion mechanisms | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Ramanan, P, Borek, D.M, Otwinowski, Z, Leung, D.W, Amarasinghe, G.K. | 登録日 | 2012-08-07 | 公開日 | 2012-11-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GXX
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![BU of 4gxx by Molmil](/molmil-images/mine/4gxx) | |
4GXU
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![BU of 4gxu by Molmil](/molmil-images/mine/4gxu) | |
4GXV
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![BU of 4gxv by Molmil](/molmil-images/mine/4gxv) | |
4M0Q
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![BU of 4m0q by Molmil](/molmil-images/mine/4m0q) | |
4IBG
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![BU of 4ibg by Molmil](/molmil-images/mine/4ibg) | Ebola virus VP35 bound to small molecule | 分子名称: | GLYCEROL, PHOSPHATE ION, Polymerase cofactor VP35, ... | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.413 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBB
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![BU of 4ibb by Molmil](/molmil-images/mine/4ibb) | Ebola virus VP35 bound to small molecule | 分子名称: | Polymerase cofactor VP35, {4-[(5R)-3-hydroxy-2-oxo-4-(thiophen-2-ylcarbonyl)-5-(2,4,5-trimethylphenyl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-12-08 | 公開日 | 2014-02-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBD
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![BU of 4ibd by Molmil](/molmil-images/mine/4ibd) | Ebola virus VP35 bound to small molecule | 分子名称: | 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-methylbenzoic acid, GLYCEROL, MAGNESIUM ION, ... | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBJ
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![BU of 4ibj by Molmil](/molmil-images/mine/4ibj) | Ebola virus VP35 bound to small molecule | 分子名称: | 3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35 | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBI
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![BU of 4ibi by Molmil](/molmil-images/mine/4ibi) | Ebola virus VP35 bound to small molecule | 分子名称: | 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-5-oxo-3-[3-(trifluoromethyl)benzoyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35 | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.473 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBE
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![BU of 4ibe by Molmil](/molmil-images/mine/4ibe) | Ebola virus VP35 bound to small molecule | 分子名称: | 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid, GLYCEROL, Polymerase cofactor VP35 | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBF
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![BU of 4ibf by Molmil](/molmil-images/mine/4ibf) | Ebola virus VP35 bound to small molecule | 分子名称: | (4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid, Polymerase cofactor VP35 | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.291 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBK
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![BU of 4ibk by Molmil](/molmil-images/mine/4ibk) | Ebola virus VP35 bound to small molecule | 分子名称: | 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IJF
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![BU of 4ijf by Molmil](/molmil-images/mine/4ijf) | Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain K222A/R225A/K248A/K251A mutant | 分子名称: | Polymerase cofactor VP35 | 著者 | Binning, J.B, Wang, T, Leung, D.W, Xu, W, Borek, D, Amarasinghe, G.K. | 登録日 | 2012-12-21 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | 主引用文献 | Development of RNA Aptamers Targeting Ebola Virus VP35. Biochemistry, 52, 2013
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4IBC
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![BU of 4ibc by Molmil](/molmil-images/mine/4ibc) | Ebola virus VP35 bound to small molecule | 分子名称: | DIMETHYL SULFOXIDE, Polymerase cofactor VP35, {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.745 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IJE
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![BU of 4ije by Molmil](/molmil-images/mine/4ije) | Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain R312A/K319A/R322A mutant | 分子名称: | PHOSPHATE ION, POTASSIUM ION, Polymerase cofactor VP35, ... | 著者 | Binning, J.B, Wang, T, Leung, D.W, Xu, W, Borek, D, Amarasinghe, G.K. | 登録日 | 2012-12-21 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Development of RNA Aptamers Targeting Ebola Virus VP35. Biochemistry, 52, 2013
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3KU5
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![BU of 3ku5 by Molmil](/molmil-images/mine/3ku5) | Crystal structure of a H2N2 influenza virus hemagglutinin, human like | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xu, R, Wilson, I.A. | 登録日 | 2009-11-26 | 公開日 | 2010-01-19 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic. J.Virol., 84, 2010
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