4IBE

Ebola virus VP35 bound to small molecule

Summary for 4IBE

• Entry DOI: 10.2210/pdb4ibe/pdb
• Related: 4IBB 4IBC 4IBD 4IBF 4IBG 4IBH 4IBI 4IBJ 4IBK
• Descriptor: Polymerase cofactor VP35, 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid, GLYCEROL, ... (4 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, interferon inhibitor domain, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Ebola virus (ZEBOV)
• Total number of polymer chains: 2
• Total formula weight: 29550.67

Authors

Brown, C.S.,Leung, D.W.,Xu, W.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Amarasinghe, G.K.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-12-08, release date: 2014-03-19, Last modification date: 2024-02-28)

• Primary citation: Brown, C.S.,Lee, M.S.,Leung, D.W.,Wang, T.,Xu, W.,Luthra, P.,Anantpadma, M.,Shabman, R.S.,Melito, L.M.,Macmillan, K.S.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Tonelli, M.,Olson, M.A.,Davey, R.A.,Ready, J.M.,Basler, C.F.,Amarasinghe, G.K.; In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.; J.Mol.Biol., 426:2045-2058, 2014; PubMed: 24495995; DOI: 10.1016/j.jmb.2014.01.010

Experimental method

X-RAY DIFFRACTION (1.95 Å)