4IBK
Ebola virus VP35 bound to small molecule
Summary for 4IBK
Entry DOI | 10.2210/pdb4ibk/pdb |
Related | 4IBB 4IBC 4IBD 4IBE 4IBF 4IBG 4IBH 4IBI 4IBJ |
Descriptor | Polymerase cofactor VP35, 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | interferon inhibitor domain, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Ebola virus (ZEBOV) |
Total number of polymer chains | 2 |
Total formula weight | 29706.05 |
Authors | Brown, C.S.,Leung, D.W.,Xu, W.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Amarasinghe, G.K. (deposition date: 2012-12-08, release date: 2014-03-19, Last modification date: 2024-02-28) |
Primary citation | Brown, C.S.,Lee, M.S.,Leung, D.W.,Wang, T.,Xu, W.,Luthra, P.,Anantpadma, M.,Shabman, R.S.,Melito, L.M.,Macmillan, K.S.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Tonelli, M.,Olson, M.A.,Davey, R.A.,Ready, J.M.,Basler, C.F.,Amarasinghe, G.K. In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426:2045-2058, 2014 Cited by PubMed: 24495995DOI: 10.1016/j.jmb.2014.01.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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