2X01
| CRYSTAL STRUCTURE OF THE OXA-10 S67A MUTANT AT PH 7 | 分子名称: | BETA-LACTAMASE OXA-10, DIMETHYL SULFOXIDE, SULFATE ION, ... | 著者 | Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Galleni, M, Charlier, P. | 登録日 | 2009-12-04 | 公開日 | 2010-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Evidence of Chloride Inhibition and Impact of the Hydrophobic Core on the Lysine Carboxylated in Class D Beta-Lactamase To be Published
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2WGI
| Crystal structure of the acyl-enzyme OXA-10 W154A-benzylpenicillin at pH 6 | 分子名称: | BETA-LACTAMASE OXA-10, GLYCEROL, OPEN FORM - PENICILLIN G | 著者 | Vercheval, L, Falzone, C, Sauvage, E, Herman, R, Charlier, P, Galleni, M, Kerff, F. | 登録日 | 2009-04-20 | 公開日 | 2009-11-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Critical Role of Tryptophan 154 for the Activity and Stability of Class D Beta-Lactamases. Biochemistry, 48, 2009
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1ZC2
| Crystal Structure of plasmid-encoded class C beta-lactamase CMY-2 complexed with citrate molecule | 分子名称: | CITRIC ACID, beta-lactamase class C | 著者 | Bauvois, C, Jacquamet, L, Fieulaine, S, Frere, J.-M, Galleni, M, Ferrer, J.-L. | 登録日 | 2005-04-10 | 公開日 | 2006-04-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Crystallographic structure of plasmid-encoded CMY-2 beta-lactamase revealed citrate molecule in the active site. To be Published
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4D2O
| Crystal structure of the class A extended-spectrum beta-lactamase PER- 2 | 分子名称: | PER-2 BETA-LACTAMASE | 著者 | Power, P, Herman, R, Ruggiero, M, Kerff, F, Galleni, M, Gutkind, G, Charlier, P, Sauvage, E. | 登録日 | 2014-05-12 | 公開日 | 2014-05-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of the Extended-Spectrum Beta-Lactamase Per- 2 and Insights Into the Role of Specific Residues in the Interaction with Beta-Lactams and Beta-Lactamase Inhibitors. Antimicrob.Agents Chemother., 58, 2014
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5AAY
| TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | 分子名称: | NF-KAPPA-B ESSENTIAL MODULATOR, ZINC ION | 著者 | Thurston, T.l, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | 登録日 | 2015-07-31 | 公開日 | 2016-07-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy. Embo J., 35, 2016
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5AAZ
| TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | 分子名称: | OPTINEURIN, ZINC ION | 著者 | Thurston, T.l, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | 登録日 | 2015-07-31 | 公開日 | 2016-07-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy. Embo J., 35, 2016
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5AAQ
| TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | 分子名称: | CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2, ZINC ION | 著者 | Thurston, T.L, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | 登録日 | 2015-07-28 | 公開日 | 2016-07-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy. Embo J., 35, 2016
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7STW
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7PA5
| Complex between the beta-lactamase CMY-2 with an inhibitory nanobody | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | 著者 | Frederic Cawez, F.C, Frederic Kerff, F.K, Moreno Galleni, M.G, Raphael Herman, R.H. | 登録日 | 2021-07-29 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.184 Å) | 主引用文献 | Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C beta-Lactamases. Antimicrob.Agents Chemother., 67, 2023
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7DOO
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5DPX
| 1,2,4-Triazole-3-thione compounds as inhibitors of L1, di-zinc metallo-beta-lactamases. | 分子名称: | 5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione, Metallo-beta-lactamase L1 type 3, SULFATE ION, ... | 著者 | Nauton, L, Garau, G, Khan, R, Dideberg, O. | 登録日 | 2015-09-14 | 公開日 | 2017-01-11 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-beta-lactamases. ChemMedChem, 12, 2017
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2QDS
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2GKL
| Crystal structure of the zinc carbapenemase CPHA in complex with the inhibitor pyridine-2,4-dicarboxylate | 分子名称: | Beta-lactamase, GLYCEROL, PYRIDINE-2,4-DICARBOXYLIC ACID, ... | 著者 | Garau, G, Dideberg, O. | 登録日 | 2006-04-03 | 公開日 | 2007-03-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Competitive Inhibitors of the CphA Metallo-{beta}-Lactamase from Aeromonas hydrophila Antimicrob.Agents Chemother., 51, 2007
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2QDT
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1X8I
| Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem | 分子名称: | 5H-PYRAZOLO(1,2-A)(1,2,4)TRIAZOL-4-IUM, 6-((2-CARBOXY-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-EN-3-YL)THIO)-6,7-DIHYDRO-, HYDROXIDE, ... | 著者 | Garau, G, Dideberg, O. | 登録日 | 2004-08-18 | 公開日 | 2004-12-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Metallo-beta-lactamase Enzyme in Action: Crystal Structures of the Monozinc Carbapenemase CphA and its Complex with Biapenem J.Mol.Biol., 345, 2005
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1X8G
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1X8H
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1DXK
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3IOF
| Crystal structure of CphA N220G mutant with inhibitor 10a | 分子名称: | Beta-lactamase, GLYCEROL, SULFATE ION, ... | 著者 | Delbruck, H, Bebrone, C, Hoffmann, K.M.V. | 登録日 | 2009-08-14 | 公開日 | 2010-06-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-beta-lactamases J.Med.Chem., 53, 2010
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3IOG
| Crystal structure of CphA N220G mutant with inhibitor 18 | 分子名称: | Beta-lactamase, GLYCEROL, SULFATE ION, ... | 著者 | Delbruck, H, Bebrone, C, Hoffmann, K.M.V. | 登録日 | 2009-08-14 | 公開日 | 2010-06-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-beta-lactamases J.Med.Chem., 53, 2010
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7PP0
| Crystal structure of the VIM-2 acquired metallo-beta-Lactamase in complex with compound 28 (JMV-7038) | 分子名称: | 2-[2-[3-[3-(2-morpholin-4-ylethoxy)phenyl]-5-sulfanylidene-1H-1,2,4-triazol-4-yl]ethyl]benzoic acid, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ... | 著者 | Tassone, G, Benvenuti, M, Verdirosa, F, Corsica, G, Chelini, G, De Luca, F, Docquier, J.D, Pozzi, C, Mangani, S. | 登録日 | 2021-09-10 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-beta-Lactamase Inhibitors. Chemmedchem, 17, 2022
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6YRP
| Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with JMV-4690 (Cpd 31) | 分子名称: | 1,2-ETHANEDIOL, 2-[[[3-(5-methoxy-2-oxidanyl-phenyl)-5-sulfanylidene-1~{H}-1,2,4-triazol-4-yl]amino]methyl]benzoic acid, ACETATE ION, ... | 著者 | Docquier, J.D, Pozzi, C, De Luca, F, Benvenuti, M, Mangani, S. | 登録日 | 2020-04-20 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 208, 2020
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3O9O
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1BVT
| METALLO-BETA-LACTAMASE FROM BACILLUS CEREUS 569/H/9 | 分子名称: | BICARBONATE ION, PROTEIN (BETA-LACTAMASE), ZINC ION | 著者 | Carfi, A, Duee, E, Dideberg, O. | 登録日 | 1998-09-18 | 公開日 | 1998-09-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | 1.85 A resolution structure of the zinc (II) beta-lactamase from Bacillus cereus. Acta Crystallogr.,Sect.D, 54, 1998
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2BMI
| METALLO-BETA-LACTAMASE | 分子名称: | PROTEIN (CLASS B BETA-LACTAMASE), SODIUM ION, ZINC ION | 著者 | Carfi, A, Duee, E, Dideberg, O. | 登録日 | 1998-09-17 | 公開日 | 1998-09-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | X-ray structure of the ZnII beta-lactamase from Bacteroides fragilis in an orthorhombic crystal form. Acta Crystallogr.,Sect.D, 54, 1998
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