7PP0

Crystal structure of the VIM-2 acquired metallo-beta-Lactamase in complex with compound 28 (JMV-7038)

Summary for 7PP0

• Entry DOI: 10.2210/pdb7pp0/pdb
• Descriptor: Metallo-beta-lactamase VIM-2-like protein, ZINC ION, ACETATE ION, ... (5 entities in total)
• Functional Keywords: metallo-beta-lactamase, vim-2, triazole-thione, inhibitor, zinc, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 26308.18

Authors

Tassone, G.,Benvenuti, M.,Verdirosa, F.,Corsica, G.,Chelini, G.,De Luca, F.,Docquier, J.D.,Pozzi, C.,Mangani, S. (deposition date: 2021-09-10, release date: 2022-03-16, Last modification date: 2024-01-31)

• Primary citation: Verdirosa, F.,Gavara, L.,Sevaille, L.,Tassone, G.,Corsica, G.,Legru, A.,Feller, G.,Chelini, G.,Mercuri, P.S.,Tanfoni, S.,Sannio, F.,Benvenuti, M.,Cerboni, G.,De Luca, F.,Bouajila, E.,Vo Hoang, Y.,Licznar-Fajardo, P.,Galleni, M.,Pozzi, C.,Mangani, S.,Docquier, J.D.,Hernandez, J.F.; 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-beta-Lactamase Inhibitors.; Chemmedchem, 17:e202100699-e202100699, 2022; PubMed: 35050549; DOI: 10.1002/cmdc.202100699

Experimental method

X-RAY DIFFRACTION (1.73 Å)