7DOO

Crystal Structure of PenA beta-Lactamase-Avibactam Complex

Summary for 7DOO

• Entry DOI: 10.2210/pdb7doo/pdb
• Related: 3w4q
• Descriptor: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total)
• Functional Keywords: hydrolase
• Biological source: Burkholderia multivorans ATCC 17616
• Total number of polymer chains: 3
• Total formula weight: 89158.51

Authors

Nukaga, M.,Papp-Wallace, K.M.,Bonomo, R.A. (deposition date: 2020-12-15, release date: 2020-12-23, Last modification date: 2023-11-29)

• Primary citation: Papp-Wallace, K.M.,Becka, S.A.,Zeiser, E.T.,Ohuchi, N.,Mojica, M.F.,Gatta, J.A.,Falleni, M.,Tosi, D.,Borghi, E.,Winkler, M.L.,Wilson, B.M.,LiPuma, J.J.,Nukaga, M.,Bonomo, R.A.; Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.; Acs Infect Dis., 3:502-511, 2017; PubMed: 28264560; DOI: 10.1021/acsinfecdis.7b00020

Experimental method

X-RAY DIFFRACTION (1.6 Å)