2WGI

Crystal structure of the acyl-enzyme OXA-10 W154A-benzylpenicillin at pH 6

Summary for 2WGI

Entry DOI	10.2210/pdb2wgi/pdb
Related	1E3U 1E4D 1EWZ 1FOF 1K4E 1K4F 1K54 1K55 1K56 1K57 1K6R 1K6S
Descriptor	BETA-LACTAMASE OXA-10, OPEN FORM - PENICILLIN G, GLYCEROL, ... (4 entities in total)
Functional Keywords	hydrolase-antibiotic complex, hydrolase antibiotic complex, lysine carboxylation, hydrolase, acyl-enzyme, antibiotic resistance, class d beta-lactamase, hydrolase/antibiotic
Biological source	PSEUDOMONAS AERUGINOSA
Total number of polymer chains	2
Total formula weight	55959.72
Authors	Vercheval, L.,Falzone, C.,Sauvage, E.,Herman, R.,Charlier, P.,Galleni, M.,Kerff, F. (deposition date: 2009-04-20, release date: 2009-11-10, Last modification date: 2023-12-13)
Primary citation	Baurin, S.,Vercheval, L.,Bouillenne, F.,Falzone, C.,Brans, A.,Jacquamet, L.,Ferrer, J.L.,Sauvage, E.,Dehareng, D.,Frere, J.M.,Charlier, P.,Galleni, M.,Kerff, F. Critical Role of Tryptophan 154 for the Activity and Stability of Class D Beta-Lactamases. Biochemistry, 48:11252-, 2009 Cited by PubMed: 19860471 DOI: 10.1021/BI901548C PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation