3QYB
| |
3O51
| Crystal structure of anthranilamide 10 bound to AuroraA | 分子名称: | N-[4-({3-[5-fluoro-2-(methylideneamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-2-(phenylamino)benzamide, cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6 | 著者 | Huang, X. | 登録日 | 2010-07-27 | 公開日 | 2010-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor. J.Med.Chem., 53, 2010
|
|
3QYE
| Crystal Structure of Human TBC1D1 RabGAP domain | 分子名称: | TBC1 domain family member 1 | 著者 | Park, S.Y, Shoelson, S.E. | 登録日 | 2011-03-03 | 公開日 | 2011-03-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. J.Biol.Chem., 286, 2011
|
|
3PBO
| Crystal structure of PBP3 complexed with ceftazidime | 分子名称: | ACYLATED CEFTAZIDIME, Penicillin-binding protein 3 | 著者 | Han, S. | 登録日 | 2010-10-20 | 公開日 | 2010-12-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3PBT
| Crystal structure of PBP3 complexed with MC-1 | 分子名称: | (4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-1-[({4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-4-formyl-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oate, Penicillin-binding protein 3 | 著者 | Han, S, Evdokimov, A. | 登録日 | 2010-10-20 | 公開日 | 2010-12-22 | 最終更新日 | 2012-02-08 | 実験手法 | X-RAY DIFFRACTION (1.641 Å) | 主引用文献 | Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3PD8
| X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution | 分子名称: | (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid, ACETIC ACID, CACODYLATE ION, ... | 著者 | Frydenvang, K, Kastrup, J.S. | 登録日 | 2010-10-22 | 公開日 | 2010-12-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.476 Å) | 主引用文献 | Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J. Med. Chem., 53, 2010
|
|
3OII
| |
3OIJ
| |
3RFI
| |
3PMH
| |
3PIQ
| Crystal structure of human 2909 Fab, a quaternary structure-specific antibody against HIV-1 | 分子名称: | Human monoclonal antibody 2909 Fab heavy chain, Human monoclonal antibody 2909 Fab light chain | 著者 | Changela, A, Gorny, M.K, Zolla-Pazner, S, Kwong, P.D. | 登録日 | 2010-11-07 | 公開日 | 2011-01-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.325 Å) | 主引用文献 | Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1. J.Virol., 85, 2011
|
|
3RK4
| Structure of Rhodococcus rhodochrous haloalkane dehalogenase mutant DhaA31 | 分子名称: | CHLORIDE ION, Haloalkane dehalogenase | 著者 | Lahoda, M, Stsiapanava, A, Mesters, J, Chaloupkova, R, Damborsky, J, Kuta Smatanova, I. | 登録日 | 2011-04-17 | 公開日 | 2012-04-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Crystallographic analysis of 1,2,3-trichloropropane biodegradation by the haloalkane dehalogenase DhaA31. Acta Crystallogr.,Sect.D, 70, 2014
|
|
3QAR
| Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32 | 分子名称: | 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzimidazol-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | 登録日 | 2011-01-11 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of triazine-benzimidazoles as selective inhibitors of mTOR. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3QB8
| Paramecium Chlorella Bursaria Virus1 Putative ORF A654L is a Polyamine Acetyltransferase | 分子名称: | A654L protein, COENZYME A, IMIDAZOLE | 著者 | Charlop-Powers, Z, Zhou, M.-M, Jakoncic, J, Gurnon, J, Van Etten, J. | 登録日 | 2011-01-12 | 公開日 | 2012-01-25 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase. J. Biol. Chem., 287, 2012
|
|
3Q6U
| Structure of the apo MET receptor kinase in the dually-phosphorylated, activated state | 分子名称: | Hepatocyte growth factor receptor | 著者 | Soisson, S.M, Rickert, K.W, Patel, S.B, Allison, T, Lumb, K.J. | 登録日 | 2011-01-03 | 公開日 | 2011-01-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural basis for selective small molecule kinase inhibition of activated c-Met. J.Biol.Chem., 286, 2011
|
|
3OON
| The structure of an outer membrance protein from Borrelia burgdorferi B31 | 分子名称: | Outer membrane protein (Tpn50), SULFATE ION | 著者 | Fan, Y, Bigelow, L, Feldman, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2010-08-31 | 公開日 | 2010-09-22 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi. Protein Sci., 26, 2017
|
|
3OVL
| |
3OW4
| Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors | 分子名称: | (2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine, GSK 3 beta peptide, RAC-alpha serine/threonine-protein kinase | 著者 | Dizon, F, Wu, W, Vigers, G.P.A, Brandhuber, B.J. | 登録日 | 2010-09-17 | 公開日 | 2010-11-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
|
|
3R7O
| Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog | 分子名称: | Hepatocyte growth factor receptor, N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}sulfuric diamide | 著者 | Soisson, S.M, Rickert, K, Patel, S.B, Munshi, S, Lumb, K.J. | 登録日 | 2011-03-22 | 公開日 | 2012-02-01 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for selective small molecule kinase inhibition of activated c-Met. J.Biol.Chem., 286, 2011
|
|
3OTQ
| Soluble Epoxide Hydrolase in complex with pyrazole antagonist | 分子名称: | Epoxide hydrolase 2, N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide | 著者 | Farrow, N.A. | 登録日 | 2010-09-13 | 公開日 | 2010-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain. Bioorg.Med.Chem.Lett., 20, 2010
|
|
3OW6
| Crystal Structure of HSP90 with N-Aryl-benzimidazolone I | 分子名称: | 1-(2,4-dihydroxyphenyl)-1,3-dihydro-2H-benzimidazol-2-one, Heat shock protein HSP 90-alpha | 著者 | Park, C.H. | 登録日 | 2010-09-17 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
|
|
3PHV
| X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES | 分子名称: | UNLIGANDED HIV-1 PROTEASE | 著者 | Lapatto, R, Blundell, T.L, Hemmings, A, Wilderspin, A, Wood, S.P, Danley, D.E, Geoghegan, K.F, Hawrylik, S.J, Hobart, P.M. | 登録日 | 1991-11-04 | 公開日 | 1992-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. Nature, 342, 1989
|
|
3S6W
| |
3SE9
| Crystal structure of broadly and potently neutralizing antibody VRC-PG04 in complex with HIV-1 gp120 | 分子名称: | (R,R)-2,3-BUTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kwong, P.D, Zhou, T. | 登録日 | 2011-06-10 | 公開日 | 2011-08-10 | 最終更新日 | 2021-04-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science, 333, 2011
|
|
2QF6
| HSP90 complexed with A56322 | 分子名称: | 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE, Heat shock protein HSP 90-alpha | 著者 | Park, C.H. | 登録日 | 2007-06-26 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies. Chem.Biol.Drug Des., 70, 2007
|
|