HSP90 complexed with A56322

Summary for 2QF6

DescriptorHeat shock protein HSP 90-alpha, 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE (3 entities in total)
Functional Keywordsprotein-inhibitor complex, chaperone
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P07900
Total number of polymer chains4
Total molecular weight93857.62
Park, C.H. (deposition date: 2007-06-26, release date: 2008-07-01, Last modification date: 2011-07-13)
Primary citation
Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chem.Biol.Drug Des., 70:1-12, 2007
PubMed: 17630989 (PDB entries with the same primary citation)
DOI: 10.1111/j.1747-0285.2007.00535.x
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers252.6%5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2qf6
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Molmil generated image of 2qf6
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Molmil generated image of 2qf6
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