3PHV

X-RAY ANALYSIS OF HIV-1 PROTEINASE AT 2.7 ANGSTROMS RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES

Summary for 3PHV

DescriptorUNLIGANDED HIV-1 PROTEASE (1 entity in total)
Functional Keywordshydrolase, aspartic proteinase
Biological sourceHIV-1 M:B_HXB2R
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04585
Total number of polymer chains1
Total molecular weight10803.76
Authors
Lapatto, R.,Blundell, T.L.,Hemmings, A.,Wilderspin, A.,Wood, S.P.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Hobart, P.M. (deposition date: 1991-11-04, release date: 1992-01-15, Last modification date: 2017-11-29)
Primary citation
Lapatto, R.,Blundell, T.,Hemmings, A.,Overington, J.,Wilderspin, A.,Wood, S.,Merson, J.R.,Whittle, P.J.,Danley, D.E.,Geoghegan, K.F.,Hawrylik, S.J.,Lee, S.E.,Scheld, K.G.,Hobart, P.M.
X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes.
Nature, 342:299-302, 1989
PubMed: 2682266 (PDB entries with the same primary citation)
DOI: 10.1038/342299a0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers617.2%43.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report