3PBT

Crystal structure of PBP3 complexed with MC-1

Summary for 3PBT

• Entry DOI: 10.2210/pdb3pbt/pdb
• Related: 3PBN 3PBO 3PBQ 3PBR 3PBS
• Descriptor: Penicillin-binding protein 3, (4S,7Z)-7-(2-amino-1,3-thiazol-4-yl)-1-[({4-[(2R)-2,3-dihydroxypropyl]-3-(4,5-dihydroxypyridin-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}sulfonyl)amino]-4-formyl-10,10-dimethyl-1,6-dioxo-9-oxa-2,5,8-triazaundec-7-en-11-oate (3 entities in total)
• Functional Keywords: pbp3, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 59045.10

Authors

Han, S.,Evdokimov, A. (deposition date: 2010-10-20, release date: 2010-12-22, Last modification date: 2012-02-08)

• Primary citation: Han, S.,Zaniewski, R.P.,Marr, E.S.,Lacey, B.M.,Tomaras, A.P.,Evdokimov, A.,Miller, J.R.,Shanmugasundaram, V.; Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.; Proc.Natl.Acad.Sci.USA, 107:22002-22007, 2010; PubMed: 21135211; DOI: 10.1073/pnas.1013092107

Experimental method

X-RAY DIFFRACTION (1.641 Å)