3PBQ

Crystal structure of PBP3 complexed with imipenem

Summary for 3PBQ

• Entry DOI: 10.2210/pdb3pbq/pdb
• Related: 3PBN 3PBO 3PBR 3PBS 3PBT
• Descriptor: Penicillin-binding protein 3, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: pbp, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 58630.82

Authors

Han, S. (deposition date: 2010-10-20, release date: 2010-12-22, Last modification date: 2011-08-24)

• Primary citation: Han, S.,Zaniewski, R.P.,Marr, E.S.,Lacey, B.M.,Tomaras, A.P.,Evdokimov, A.,Miller, J.R.,Shanmugasundaram, V.; Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.; Proc.Natl.Acad.Sci.USA, 107:22002-22007, 2010; PubMed: 21135211; DOI: 10.1073/pnas.1013092107

Experimental method

X-RAY DIFFRACTION (1.7 Å)