3R7O

Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog

Summary for 3R7O

Entry DOI	10.2210/pdb3r7o/pdb
Descriptor	Hepatocyte growth factor receptor, N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}sulfuric diamide (3 entities in total)
Functional Keywords	tyrosine kinase, phosphotyrosine, 1234, 1235, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	35678.02
Authors	Soisson, S.M.,Rickert, K.,Patel, S.B.,Munshi, S.,Lumb, K.J. (deposition date: 2011-03-22, release date: 2012-02-01, Last modification date: 2017-11-08)
Primary citation	Rickert, K.W.,Patel, S.B.,Allison, T.J.,Byrne, N.J.,Darke, P.L.,Ford, R.E.,Guerin, D.J.,Hall, D.L.,Kornienko, M.,Lu, J.,Munshi, S.K.,Reid, J.C.,Shipman, J.M.,Stanton, E.F.,Wilson, K.J.,Young, J.R.,Soisson, S.M.,Lumb, K.J. Structural basis for selective small molecule kinase inhibition of activated c-Met. J.Biol.Chem., 286:11218-11225, 2011 Cited by PubMed: 21247903 DOI: 10.1074/jbc.M110.204404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation