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3B6Q
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BU of 3b6q by Molmil
Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with Glutamate at 2.0 Resolution
分子名称: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION
著者Cho, Y, Lolis, E, Howe, J.R.
登録日2007-10-29
公開日2008-02-05
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.
J.Neurosci., 28, 2008
3B6W
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BU of 3b6w by Molmil
Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution
分子名称: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION
著者Cho, Y, Lolis, E, Howe, J.R.
登録日2007-10-29
公開日2008-02-05
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.
J.Neurosci., 28, 2008
2FZM
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BU of 2fzm by Molmil
Structure of the E. coli PutA proline dehydrogenase domain reduced by dithionite and complexed with SO2
分子名称: Bifunctional protein putA, Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase), FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Tanner, J.J.
登録日2006-02-09
公開日2007-04-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Redox-induced changes in flavin structure and roles of flavin N(5) and the ribityl 2'-OH group in regulating PutA--membrane binding.
Biochemistry, 46, 2007
2FZN
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BU of 2fzn by Molmil
Structure of the E. coli PutA proline dehydrogenase domain reduced by dithionite and complexed with proline
分子名称: Bifunctional protein putA, Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase), FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Tanner, J.J.
登録日2006-02-09
公開日2006-12-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Hydrogen Bonding Interactions of the 2-OH Ribityl Group and the N(5) Position of the FAD Cofactor Regulate PutA-membrane Associations in Escherichia coli
To be Published
5C7J
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BU of 5c7j by Molmil
CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT
分子名称: E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C
著者Walker, J.R, Hu, J, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC)
登録日2015-06-24
公開日2016-03-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPK
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BU of 5hpk by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1
分子名称: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
著者Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A.
登録日2016-01-20
公開日2016-03-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.431 Å)
主引用文献System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPT
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BU of 5hpt by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1, Ubv P2.3 and UBCH7
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP1, Ubiquitin variant P2.3, Ubiquitin-conjugating enzyme E2 L3
著者Wu, K.-P, Schulman, B.A.
登録日2016-01-20
公開日2016-03-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPL
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BU of 5hpl by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4
分子名称: Rsp5, Ubiquitin variant R5.4
著者Wu, K.-P, Kamadurai, H.B, Schulman, B.A.
登録日2016-01-20
公開日2016-03-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPS
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BU of 5hps by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1
分子名称: Ubiquitin variant P1.1, WWP1 HECT
著者Wu, K.-P, Mercredi, P.Y, Schulman, B.A.
登録日2016-01-20
公開日2016-03-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
6GSA
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BU of 6gsa by Molmil
Core Centromere Binding Factor 3 (CBF3) with monomeric Ndc10
分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ...
著者Zhang, W.J, Lukoynova, N, Vaughan, C.K.
登録日2018-06-13
公開日2018-08-01
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Insights into Centromere DNA Bending Revealed by the Cryo-EM Structure of the Core Centromere Binding Factor 3 with Ndc10.
Cell Rep, 24, 2018
8I71
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BU of 8i71 by Molmil
Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM)
分子名称: 3-[(8~{a}~{S})-7-[[5-ethoxycarbonyl-4-(3-fluoranyl-2-methyl-phenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-3-oxidanylidene-5,6,8,8~{a}-tetrahydro-1~{H}-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid, CHLORIDE ION, Capsid protein, ...
著者Zhou, Z, Xu, Z.H.
登録日2023-01-30
公開日2023-03-22
最終更新日2023-04-05
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.
J.Med.Chem., 66, 2023
5V5H
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BU of 5v5h by Molmil
OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.2
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RNA-directed RNA polymerase L, SODIUM ION, ...
著者Khare, B, Mark, B.L.
登録日2017-03-14
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
5V6A
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BU of 5v6a by Molmil
Crystal structure of the Middle East respiratory syndrome coronavirus papain-like protease bound to ubiquitin variant ME.2
分子名称: CHLORIDE ION, CITRATE ANION, ME.2, ...
著者Bailey-Elkin, B.A, Mark, B.L.
登録日2017-03-16
公開日2017-05-10
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
3IUF
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BU of 3iuf by Molmil
Crystal structure of the C2H2-type zinc finger domain of human ubi-d4
分子名称: ZINC ION, Zinc finger protein ubi-d4
著者Tempel, W, Xu, C, Bian, C, Adams-Cioaba, M, Eryilmaz, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
登録日2009-08-31
公開日2009-11-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.
Biochem.Biophys.Res.Commun., 413, 2011
8SRO
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BU of 8sro by Molmil
FoxP3 tetramer on TTTG repeats
分子名称: DNA 72-mer, Forkhead box protein P3
著者Leng, F, Hur, S.
登録日2023-05-05
公開日2023-10-18
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Nature, 624, 2023
8SRP
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BU of 8srp by Molmil
FoxP3 forms Ladder-like multimer to bridge TTTG repeats
分子名称: DNA 72-mer, Forkhead box protein P3
著者Leng, F, Hur, S.
登録日2023-05-05
公開日2023-10-18
最終更新日2023-12-27
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Nature, 624, 2023
7YV4
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BU of 7yv4 by Molmil
Crystal structure of human UCHL3 in complex with Farrerol
分子名称: (2~{S})-2-(4-hydroxyphenyl)-6,8-dimethyl-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Ubiquitin carboxyl-terminal hydrolase isozyme L3
著者Mao, Z.Y, Xu, X.J, Zhang, W.T.
登録日2022-08-18
公開日2023-04-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.
Nat Commun, 14, 2023
8DEA
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BU of 8dea by Molmil
Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
分子名称: 1-[(3-acetylphenyl)acetyl]-N-(6-bromopyridin-2-yl)-L-prolinamide, Complement factor D, GLYCEROL
著者Raman, K, Babu, Y.S.
登録日2022-06-20
公開日2022-11-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.214 Å)
主引用文献Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg.Med.Chem., 74, 2022
8DG6
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BU of 8dg6 by Molmil
Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
分子名称: 1-{2-[(2S)-2-{[(3-chloro-2-fluorophenyl)methyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}-1H-indazole-3-carboxamide, Complement factor D
著者Raman, K, Babu, Y.S.
登録日2022-06-23
公開日2022-11-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.986 Å)
主引用文献Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg.Med.Chem., 74, 2022
8D95
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BU of 8d95 by Molmil
Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
分子名称: Complement factor D, N-(6-bromopyridin-2-yl)-1-[(3-cyanophenyl)acetyl]-L-prolinamide
著者Raman, K, Babu, Y.S.
登録日2022-06-09
公開日2022-11-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.166 Å)
主引用文献Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg.Med.Chem., 74, 2022
7EQ2
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BU of 7eq2 by Molmil
Crystal structure of GDP-bound Rab1a-T75D
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, COBALT HEXAMMINE(III), ...
著者Cao, Y.L, Gu, D.D, Gao, S.
登録日2021-04-28
公開日2022-11-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.55090284 Å)
主引用文献Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis
Nat.Struct.Mol.Biol., 2024
8JNJ
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BU of 8jnj by Molmil
Structure of R932A/K1147A/H1148A mutant AE2
分子名称: Anion exchange protein 2
著者Yin, Y.X, Ding, D.
登録日2023-06-06
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural and functional insights into the lipid regulation of human anion exchanger 2.
Nat Commun, 15, 2024
8JNI
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BU of 8jni by Molmil
Structure of AE2 in complex with PIP2
分子名称: Anion exchange protein 2, CHLORIDE ION, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate
著者Yin, Y.X, Ding, D.
登録日2023-06-06
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional insights into the lipid regulation of human anion exchanger 2.
Nat Commun, 15, 2024
5CUM
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BU of 5cum by Molmil
Crystal structure of Human Defensin-5 Y27A mutant crystal form 1.
分子名称: CALCIUM ION, CHLORIDE ION, Defensin-5, ...
著者Tolbert, W.D, Gohain, N, Pazgier, M.
登録日2015-07-24
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Immunity, 2018
6PWW
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BU of 6pww by Molmil
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome
分子名称: DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ...
著者Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U.
登録日2019-07-23
公開日2019-12-18
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019

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