7YV4
Crystal structure of human UCHL3 in complex with Farrerol
Summary for 7YV4
Entry DOI | 10.2210/pdb7yv4/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase isozyme L3, (2~{S})-2-(4-hydroxyphenyl)-6,8-dimethyl-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one (3 entities in total) |
Functional Keywords | activator, complex, ubiquitinase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 26513.88 |
Authors | Mao, Z.Y.,Xu, X.J.,Zhang, W.T. (deposition date: 2022-08-18, release date: 2023-04-19, Last modification date: 2023-11-29) |
Primary citation | Zhang, W.,Wang, M.,Song, Z.,Fu, Q.,Chen, J.,Zhang, W.,Gao, S.,Sun, X.,Yang, G.,Zhang, Q.,Yang, J.,Tang, H.,Wang, H.,Kou, X.,Wang, H.,Mao, Z.,Xu, X.,Gao, S.,Jiang, Y. Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer. Nat Commun, 14:1838-1838, 2023 Cited by PubMed: 37012254DOI: 10.1038/s41467-023-37576-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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