2G2Z
| Structure of E.coli FabD complexed with malonyl-CoA | 分子名称: | COENZYME A, MALONIC ACID, Malonyl CoA-acyl carrier protein transacylase | 著者 | Oefner, Christian | 登録日 | 2006-02-17 | 公開日 | 2006-06-27 | 最終更新日 | 2015-04-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr.,Sect.D, 62, 2006
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5C6B
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5C69
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2G2Y
| Structure of E.coli FabD complexed with malonate | 分子名称: | MALONATE ION, Malonyl CoA-acyl carrier protein transacylase | 著者 | Oefner, C. | 登録日 | 2006-02-17 | 公開日 | 2006-05-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr.,Sect.D, 62, 2006
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2G2O
| Structure of E.coli FabD complexed with sulfate | 分子名称: | Malonyl CoA-acyl carrier protein transacylase, SULFATE ION | 著者 | Oefner, C. | 登録日 | 2006-02-16 | 公開日 | 2006-05-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr.,Sect.D, 62, 2006
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2G1H
| Structure of E.coli FabD complexed with glycerol | 分子名称: | GLYCEROL, Malonyl CoA-acyl carrier protein transacylase | 著者 | Oefner, C. | 登録日 | 2006-02-14 | 公開日 | 2006-05-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr.,Sect.D, 62, 2006
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4DPG
| Crystal Structure of Human LysRS: P38/AIMP2 Complex I | 分子名称: | ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | 著者 | Fang, P, Wang, J, Bennett, S.P, Guo, M. | 登録日 | 2012-02-13 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.844 Å) | 主引用文献 | Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription. Mol.Cell, 49, 2013
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1QXY
| Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle 618 | 分子名称: | (2S)-2-AMINO-4-(METHYLSULFANYL)-1-PYRIDIN-2-YLBUTANE-1,1-DIOL, ACETATE ION, COBALT (II) ION, ... | 著者 | Douangamath, A, Dale, G.E, D'Arcy, A, Oefner, C. | 登録日 | 2003-09-09 | 公開日 | 2004-03-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47, 2004
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1Q0Q
| Crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose-5-phosphate | 分子名称: | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mac Sweeney, A, Lange, R, D'Arcy, A, Douangamath, A, Surivet, J.-P, Oefner, C. | 登録日 | 2003-07-17 | 公開日 | 2004-07-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. J.Mol.Biol., 345, 2005
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2B0R
| Crystal Structure of Cyclase-Associated Protein from Cryptosporidium parvum | 分子名称: | UNKNOWN ATOM OR ION, possible adenyl cyclase-associated protein | 著者 | Tempel, W, Dong, A, Zhao, Y, Lew, J, Kozieradzki, I, Alam, Z, Melone, M, Wasney, G, Vedadi, M, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Hui, R, Bochkarev, A, Artz, J, Structural Genomics Consortium (SGC) | 登録日 | 2005-09-14 | 公開日 | 2005-09-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector J.Biol.Chem., 151, 2010
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1Q0L
| Crystal structure of DXR in complex with fosmidomycin | 分子名称: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mac Sweeney, A, Lange, R, D'Arcy, A, Douangamath, A, Surivet, J.-P, Oefner, C. | 登録日 | 2003-07-16 | 公開日 | 2004-07-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. J.Mol.Biol., 345, 2005
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1Q0H
| Crystal structure of selenomethionine-labelled DXR in complex with fosmidomycin | 分子名称: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, CITRIC ACID, ... | 著者 | Mac Sweeney, A, Lange, R, D'Arcy, A, Douangamath, A, Surivet, J.-P, Oefner, C. | 登録日 | 2003-07-16 | 公開日 | 2004-07-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. J.Mol.Biol., 345, 2005
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1QXZ
| Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119 | 分子名称: | (2S)-2-AMINO-4-(METHYLSULFANYL)-1-(1,3-THIAZOL-2-YL)BUTANE-1,1-DIOL, COBALT (II) ION, methionyl aminopeptidase | 著者 | Douangamath, A, Dale, G.E, D'Arcy, A, Oefner, C. | 登録日 | 2003-09-09 | 公開日 | 2004-03-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47, 2004
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1QXW
| Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135. | 分子名称: | (3S)-3-AMINO-1-(CYCLOPROPYLAMINO)HEPTANE-2,2-DIOL, ACETATE ION, COBALT (II) ION, ... | 著者 | Douangamath, A, Dale, G.E, D'Arcy, A, Oefner, C. | 登録日 | 2003-09-09 | 公開日 | 2004-03-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47, 2004
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3SOA
| Full-length human CaMKII | 分子名称: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker | 著者 | Chao, L.H, Kuriyan, J. | 登録日 | 2011-06-30 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.5501 Å) | 主引用文献 | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Cell(Cambridge,Mass.), 146, 2011
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6O04
| M.tb MenD IntII bound with Inhibitor | 分子名称: | (1~{R},2~{S},5~{S},6~{S})-2-[(1~{S})-1-[3-[(4-azanylidene-2-methyl-1~{H}-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl (phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-1,4-bis(oxidanyl)-4-oxidanylidene-butyl]-6-oxidanyl-5-(3-oxid anyl-3-oxidanylidene-prop-1-en-2-yl)oxy-cyclohex-3-ene-1-carboxylic acid, 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ... | 著者 | Johnston, J.M, Bashiri, G, Bulloch, E.M, Jirgis, E.M.N, Nigon, L.V, Chuang, H, Baker, E.N. | 登録日 | 2019-02-15 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295, 2020
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6O0G
| M.tb MenD bound to Intermediate I and Inhibitor | 分子名称: | 1,4-dihydroxy-2-naphthoic acid, 2-OXOGLUTARIC ACID, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ... | 著者 | Johnston, J.M, Bashiri, G, Bulloch, E.M.M, Jirgis, E.M.N, Chuang, H, Nigon, L.V, Baker, E.N. | 登録日 | 2019-02-16 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295, 2020
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6O0J
| M.tb MenD with ThDP and Inhibitor bound | 分子名称: | 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ACETATE ION, ... | 著者 | Johnston, J.M, Bashiri, G, Bulloch, E.M.M, Jirgis, E.M.N, Nigon, L.V, Chuang, H, Ho, N.A.T, Baker, E.N. | 登録日 | 2019-02-16 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis. J.Biol.Chem., 295, 2020
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3VOZ
| Crystal structure of human glutaminase in complex with BPTES | 分子名称: | Glutaminase kidney isoform, mitochondrial, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide), ... | 著者 | Thangavelu, K, Sivaraman, J. | 登録日 | 2012-02-23 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3VOY
| Crystal structure of human glutaminase in apo form | 分子名称: | Glutaminase kidney isoform, mitochondrial, SULFATE ION | 著者 | Thangavelu, K, Sivaraman, J. | 登録日 | 2012-02-23 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3VP3
| Crystal structure of human glutaminase in complex with inhibitor 3 | 分子名称: | 5,5'-pentane-1,5-diylbis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial, ... | 著者 | Thangavelu, K, Sivaraman, J. | 登録日 | 2012-02-23 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3VP4
| Crystal structure of human glutaminase in complex with inhibitor 4 | 分子名称: | 5,5'-butane-1,4-diylbis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial | 著者 | Thangavelu, K, Sivaraman, J. | 登録日 | 2012-02-23 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3VP1
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3VP2
| Crystal structure of human glutaminase in complex with inhibitor 2 | 分子名称: | 5,5'-(sulfanediyldiethane-2,1-diyl)bis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial, ... | 著者 | Thangavelu, K, Sivaraman, J. | 登録日 | 2012-02-23 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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3VP0
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