4DPG

Crystal Structure of Human LysRS: P38/AIMP2 Complex I

Summary for 4DPG

Entry DOI	10.2210/pdb4dpg/pdb
Related	4DPJ
Descriptor	Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ... (7 entities in total)
Functional Keywords	lysyl-trna synthetase, lysrs, p38, aimp2, multi trna synthetase complex sub-complex, ligase-apoptosis complex, ligase/apoptosis
Biological source	Homo sapiens (human) More
Cellular location	Isoform Cytoplasmic: Cytoplasm, cytosol . Isoform Mitochondrial: Mitochondrion : Q15046 Cytoplasm, cytosol : Q13155
Total number of polymer chains	12
Total formula weight	503812.56
Authors	Fang, P.,Wang, J.,Bennett, S.P.,Guo, M. (deposition date: 2012-02-13, release date: 2013-02-13, Last modification date: 2024-02-28)
Primary citation	Ofir-Birin, Y.,Fang, P.,Bennett, S.P.,Zhang, H.M.,Wang, J.,Rachmin, I.,Shapiro, R.,Song, J.,Dagan, A.,Pozo, J.,Kim, S.,Marshall, A.G.,Schimmel, P.,Yang, X.L.,Nechushtan, H.,Razin, E.,Guo, M. Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription. Mol.Cell, 49:30-42, 2013 Cited by PubMed: 23159739 DOI: 10.1016/j.molcel.2012.10.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.844 Å)

Structure validation