4DPG

Crystal Structure of Human LysRS: P38/AIMP2 Complex I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Lysine--tRNA ligase	polymer	513	59240.1	8	UniProt (Q15046) Pfam (PF01336) Pfam (PF00152)	Homo sapiens (human)	Lysyl-tRNA synthetase, LysRS
2	I, J, K, L (I, J, K, L)	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	polymer	54	6072.9	4	UniProt (Q13155) Pfam (PF16780)	Homo sapiens (human)	Multisynthase complex auxiliary component p38, Protein JTV-1
3	BA, FA, JA, M, P... (F, G, H, A, B...)	LYSINE	non-polymer		147.2	8	Chemie (LYS)
4	CA, GA, KA, N, Q... (F, G, H, A, B...)	DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	non-polymer		505.2	8	Chemie (APC)
5	AA, DA, EA, HA, LA... (E, F, G, H, J...)	MAGNESIUM ION	non-polymer		24.3	12	Chemie (MG)
6	IA (H)	ALANINE	non-polymer		89.1	1	Chemie (ALA)
7	AB, PA, QA, RA, SA... (L, A, B, C, D...)	water	water		18.0	542	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 70 - 581 (UniProt: Q15046)

PDB	External Database	Details
Met 69	-	expression tag

I, J, K, L: 1 - 48 (UniProt: Q13155)

PDB	External Database	Details
His 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	498212.6
Non-Polymers*	Number of molecules	29
	Total formula weight	5600.0
All*	Total formula weight	503812.6

*Water molecules are not included.